Highly Selective Apoptotic Cell Death Induced by Halo-Salane Titanium Complexes

Immel, Timo; Debiak, Malgorzata; Groth, Ulrich; Bürkle, Alexander; Huhn, Thomas

Highly Selective Apoptotic Cell Death Induced by Halo-Salane Titanium Complexes

Dateien

ChemMedChem2009.pdfGröße: 548.35 KBDownloads: 667

Datum

2009

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

ChemMedChem. 2009, 4(5), pp. 738-741. ISSN 1860-7179. eISSN 1860-7187. Available under: doi: 10.1002/cmdc.200900038

Zusammenfassung

Halogen-substituted titanium salane complexes showed IC50 values comparable to cisplatin. In contrast to their alkyl-substituted congeners, they almost exclusively induced apoptotic cell death. This unique combination of very low IC50 values and pronounced preference for apoptosis makes them promising therapeutic agents

Fachgebiet (DDC)

540 Chemie

Schlagwörter

antitumor agents, apoptosis, cytotoxicity, structure-activity relationships, titanium complexes

Zitieren

ISO 690

IMMEL, Timo, Malgorzata DEBIAK, Ulrich GROTH, Alexander BÜRKLE, Thomas HUHN, 2009. Highly Selective Apoptotic Cell Death Induced by Halo-Salane Titanium Complexes. In: ChemMedChem. 2009, 4(5), pp. 738-741. ISSN 1860-7179. eISSN 1860-7187. Available under: doi: 10.1002/cmdc.200900038

BibTex

@article{Immel2009Highl-9689,
  year={2009},
  doi={10.1002/cmdc.200900038},
  title={Highly Selective Apoptotic Cell Death Induced by Halo-Salane Titanium Complexes},
  number={5},
  volume={4},
  issn={1860-7179},
  journal={ChemMedChem},
  pages={738--741},
  author={Immel, Timo and Debiak, Malgorzata and Groth, Ulrich and Bürkle, Alexander and Huhn, Thomas}
}

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Universitätsbibliographie

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