@article{Falsig2006infla-7174,
  year={2006},
  doi={10.1111/j.1471-4159.2005.03622.x},
  title={The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function},
  number={3},
  volume={96},
  issn={0022-3042},
  journal={Journal of Neurochemistry},
  pages={893--907},
  author={Falsig, Jeppe and Pörzgen, Peter and Lund, Søren and Schrattenholz, André and Leist, Marcel}
}

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    <dc:creator>Lund, Søren</dc:creator>
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    <dc:creator>Schrattenholz, André</dc:creator>
    <dc:contributor>Lund, Søren</dc:contributor>
    <dc:creator>Leist, Marcel</dc:creator>
    <dc:contributor>Leist, Marcel</dc:contributor>
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    <dc:contributor>Falsig, Jeppe</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:32:25Z</dc:date>
    <dcterms:bibliographicCitation>First publ. in: Journal of Neurochemistry 96 (2006), 3, pp. 893-907</dcterms:bibliographicCitation>
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    <dcterms:title>The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function</dcterms:title>
    <dcterms:abstract xml:lang="eng">Upon injury, astrocytes assume an activated state associated with the release of inflammatory mediators. To model this, we stimulated murine primary astrocytes with a complete inflammatory cytokine mix consisting of TNF-α, IL-1β and IFN-γ. We analysed the transcriptional response of 480 genes at 4 and 16 h after stimulation on a chip designed to give a representative overview over the inflammation-relevant part of the transcriptome of macrophage-like cells. The list of the 182 genes found to be significantly regulated in astrocytes revealed an intriguing co-ordinate regulation of genes linked to the biological processes of antiviral/antimicrobial defence, antigen presentation and facilitation of leucocyte invasion. The latter group was characterized by very high up-regulations of chemokine genes. We also identified regulations of a thymidylate kinase and an interferon-regulated protein with a tetratricopeptide motive, both up to now only known from macrophages. The transcriptional regulations were confirmed on the protein level by a proteomic analysis. These findings taken together suggest that activated astrocytes in brain behave similarly in many respects to inflamed macrophages in the periphery.</dcterms:abstract>
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