The Shape of Cell Death

Leist, Marcel; Nicotera, Pierluigi

The Shape of Cell Death

Dateien

Leist_M_Biochem_Biophys_Res_Commun_1997.pdfGröße: 920.98 KBDownloads: 517

Datum

1997

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Biochemical and Biophysical Research Communications. 1997, 236(1), pp. 1-9. ISSN 0006-291X. Available under: doi: 10.1006/bbrc.1997.6890

Zusammenfassung

Cell death, a scheduled event during development and tissue turnover, or the ultimate consequence of toxic or pathologic insults seems to involve a relatively limited number of execution pathways. This reflects the evolution of an organized sequence of events perhaps converging onto final common pathways that are used to dispose of unwanted or injured cells. In many cases, the ordered execution of this internal death program leads to typical morphological and biochemical changes that have been termed apoptosis. Apoptosis, often equated with developmental or programmed cell death, has been opposed to unscheduled or accidental cell lysis/necrosis. However, increasing evidence suggests that the two forms of cell demise share similar characteristics, at least in the signaling and early progression phase. Recent studies have shown that, when the intensity of the insult is very high and/or when ATP generation is deficient, cells fail to execute the ordered changes ensuing in apoptosis. Then cell lysis/necrosis supervenes before the processes leading to nuclear condensation and exposure of surface molecules can be completed. Thus, apoptosis and necrosis seem to represent only different shapes of cell demise, resulting from a more or less complete execution of the internal death program.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

LEIST, Marcel, Pierluigi NICOTERA, 1997. The Shape of Cell Death. In: Biochemical and Biophysical Research Communications. 1997, 236(1), pp. 1-9. ISSN 0006-291X. Available under: doi: 10.1006/bbrc.1997.6890

BibTex

@article{Leist1997Shape-7378,
  year={1997},
  doi={10.1006/bbrc.1997.6890},
  title={The Shape of Cell Death},
  number={1},
  volume={236},
  issn={0006-291X},
  journal={Biochemical and Biophysical Research Communications},
  pages={1--9},
  author={Leist, Marcel and Nicotera, Pierluigi}
}

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