Pathological apoptosis in the developing brain

Blomgren, Klas; Leist, Marcel; Groc, Laurent

Pathological apoptosis in the developing brain

Dateien

Blomgren_Leist_and_Groc_2007_Apoptosis_review.pdfGröße: 747.8 KBDownloads: 438

Datum

2007

Autor:innen

Blomgren, Klas

Leist, Marcel

Groc, Laurent

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Apoptosis. 2007, 12(5), pp. 993-1010. ISSN 1360-8185. Available under: doi: 10.1007/s10495-007-0754-4

Zusammenfassung

More than half of the initially-formed neurons are deleted in certain brain regions during normal development. This process, whereby cells are discretely removed without interfering with the further development of remaining cells, is called programmed cell death (PCD). The term apoptosis is used to describe certain morphological manifestations of PCD. Many of the effectors of this developmental cell death program are highly expressed in the developing brain, making it more susceptible to accidental activation of the death machinery, e.g. following hypoxia-ischemia or irradiation. Recent evidence suggests, however, that activation and regulation of cell death mechanisms under pathological conditions do not exactly mirror physiological, developmentally regulated PCD. It may be argued that the conditions after e.g. ischemia are not even compatible with the execution of PCD as we know it. Under pathological conditions cells are exposed to various stressors, including energy failure, oxidative stress and unbalanced ion fluxes. This results in parallel triggering and potential overshooting of several different cell death pathways, which then interact with one another and result in complex patterns of biochemical manifestations and cellular morphological features. These types of cell death are here called pathological apoptosis, where classical hallmarks of PCD, like pyknosis, nuclear condensation and caspase-3 activation, are combined with non-PCD features of cell death. Here we review our current knowledge of the mechanisms involved, with special focus on the potential for therapeutic intervention tailored to the needs of the developing brain.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Brain development, Hypoxia-ischemia, Irradiation

Zitieren

ISO 690

BLOMGREN, Klas, Marcel LEIST, Laurent GROC, 2007. Pathological apoptosis in the developing brain. In: Apoptosis. 2007, 12(5), pp. 993-1010. ISSN 1360-8185. Available under: doi: 10.1007/s10495-007-0754-4

BibTex

@article{Blomgren2007-05Patho-7554,
  year={2007},
  doi={10.1007/s10495-007-0754-4},
  title={Pathological apoptosis in the developing brain},
  number={5},
  volume={12},
  issn={1360-8185},
  journal={Apoptosis},
  pages={993--1010},
  author={Blomgren, Klas and Leist, Marcel and Groc, Laurent}
}

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Universitätsbibliographie

Ja