HECT E3s and human disease

Scheffner, Martin; Staub, Oliver

HECT E3s and human disease

Dateien

1471_2091_8_S1_S6.pdfGröße: 666.5 KBDownloads: 133

Datum

2007

Autor:innen

Scheffner, Martin

Staub, Oliver

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

BMC Biochemistry. 2007, 8(Suppl 1), S6. ISSN 1471-2091. eISSN 1471-2091. Available under: doi: 10.1186/1471-2091-8-S1-S6

Zusammenfassung

In a simplified view, members of the HECT E3 family have a modular structure consisting of the C-terminal HECT domain, which is catalytically involved in the attachment of ubiquitin to substrate proteins, and N-terminal extensions of variable length and sequence that mediate the substrate specificity of the respective HECT E3. Although the physiologically relevant substrates of most HECT E3s have remained elusive, it is becoming increasingly clear that HECT E3s play an important role in sporadic and hereditary human diseases including cancer, cardiovascular (Liddle's syndrome) and neurological (Angelman syndrome) disorders, and/or in disease-relevant processes including bone homeostasis, immune response and retroviral budding. Thus, molecular approaches to target the activity of distinct HECT E3s, regulators thereof, and/or of HECT E3 substrates could prove valuable in the treatment of the respective diseases.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

SCHEFFNER, Martin, Oliver STAUB, 2007. HECT E3s and human disease. In: BMC Biochemistry. 2007, 8(Suppl 1), S6. ISSN 1471-2091. eISSN 1471-2091. Available under: doi: 10.1186/1471-2091-8-S1-S6

BibTex

@article{Scheffner2007human-7704,
  year={2007},
  doi={10.1186/1471-2091-8-S1-S6},
  title={HECT E3s and human disease},
  number={Suppl 1},
  volume={8},
  issn={1471-2091},
  journal={BMC Biochemistry},
  author={Scheffner, Martin and Staub, Oliver},
  note={Article Number: S6}
}

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Universitätsbibliographie

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