Meyer, Melissa M., Schmidt, Alexander, Benrath, Justus, Konstandin, Simon, Pilz, Lothar R., Harrington, Michael G., Budjan, Johannes, Meyer, Mathias, Schad, Lothar R., Schoenberg, Stefan O. and Haneder, Stefan (2019). Cerebral sodium (Na-23) magnetic resonance imaging in patients with migraine - a case-control study. Eur. Radiol., 29 (12). S. 7055 - 7063. NEW YORK: SPRINGER. ISSN 1432-1084
Full text not available from this repository.Abstract
Objective Evaluation of MRI-derived cerebral Na-23 concentrations in patients with migraine in comparison with healthy controls. Materials and methods In this case-control study, 24 female migraine patients (mean age, 3411 years) were enrolled after evaluation of standardized questionnaires. Half (n=12) of the cohort suffered from migraine, the other half was impaired by both migraine and tension-type headaches (TTH). The combined patient cohort was matched to 12 healthy female controls (mean age, 3411 years). All participants underwent a cerebral Na-23-magnetic resonance imaging examination at 3.0 T, which included a T1w MP-RAGE sequence and a 3D density-adapted, radial gradient echo sequence for Na-23 imaging. Circular regions of interests were placed in predetermined anatomic regions: cerebrospinal fluid (CSF), gray and white matter, brain stem, and cerebellum. External Na-23 reference phantoms were used to calculate the total Na-23 tissue concentrations. Pearson's correlation, Kendall Tau, and Wilcoxon rank sum test were used for statistical analysis. Results Na-23 concentrations of all patients in the CSF were significantly higher than in healthy controls (p<0.001). The CSF of both the migraine and mixed migraine/TTH group showed significantly increased sodium concentrations compared to the control group (p=0.007 and p<0.001). Within the patient cohort, a positive correlation between pain level and TSC in the CSF (r=0.62) could be observed. Conclusion MRI-derived cerebral Na-23 concentrations in the CSF of migraine patients were found to be statistically significantly higher than in healthy controls.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||
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| URN: | urn:nbn:de:hbz:38-125968 | ||||||||||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1007/s00330-019-06299-1 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Eur. Radiol. | ||||||||||||||||||||||||||||||||||||||||||||||||
| Volume: | 29 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Number: | 12 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Page Range: | S. 7055 - 7063 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Date: | 2019 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Publisher: | SPRINGER | ||||||||||||||||||||||||||||||||||||||||||||||||
| Place of Publication: | NEW YORK | ||||||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1432-1084 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||
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| Refereed: | Yes | ||||||||||||||||||||||||||||||||||||||||||||||||
| URI: | http://kups.ub.uni-koeln.de/id/eprint/12596 |
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