Cornely, Oliver A., Alastruey-Izquierdo, Ana, Arenz, Dorothee, Chen, Sharon C. A., Dannaoui, Eric, Hochhegger, Bruno, Hoenigl, Martin ORCID: 0000-0002-1653-2824, Jensen, Henrik E., Lagrou, Katrien, Lewis, Russell E., Mellinghoff, Sibylle C., Mer, Mervyn, Pana, Zoi D., Seidel, Danila, Sheppard, Donald C., Wahba, Roger, Akova, Murat, Alanio, Alexandre, Al-Hatmi, Abdullah M. S., Arikan-Akdagli, Sevtap, Badali, Hamid, Ben-Ami, Ronen ORCID: 0000-0003-0628-0798, Bonifaz, Alexandro ORCID: 0000-0003-2045-3317, Bretagne, Stephane, Castagnola, Elio, Chayakulkeeree, Methee ORCID: 0000-0002-4582-4914, Colombo, Arnaldo L., Corzo-Leon, Dora E., Drgona, Lubos, Groll, Andreas H., Guinea, Jesus, Heussel, Claus-Peter, Ibrahim, Ashraf S., Kanj, Souha S., Klimko, Nikolay, Lackner, Michaela, Lamoth, Frederic ORCID: 0000-0002-1023-5597, Lanternier, Fanny, Lass-Floerl, Cornelia, Lee, Dong-Gun, Lehrnbecher, Thomas, Lmimouni, Badre E., Mares, Mihai, Maschmeyer, Georg, Meis, Jacques F., Meletiadis, Joseph, Morrissey, C. Orla, Nucci, Marcio, Oladele, Rita, Pagano, Livio, Pasqualotto, Alessandro, Patel, Atul, Racil, Zdenek, Richardson, Malcolm, Roilides, Emmanuel, Ruhnke, Markus, Seyedmousavi, Seyedmojtaba, Sidharthan, Neeraj, Singh, Nina, Sinko, Janos, Skiada, Anna, Slavin, Monica, Soman, Rajeev, Spellberg, Brad, Steinbach, William, Tan, Ban Hock, Ullmann, Andrew J., Vehreschild, Joerg J., Vehreschild, Maria J. G. T., Walsh, Thomas J., White, P. Lewis, Wiederhold, Nathan P., Zaoutis, Theoklis and Chakrabarti, Arunaloke (2019). Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect. Dis., 19 (12). S. E405 - 17. OXFORD: ELSEVIER SCI LTD. ISSN 1474-4457

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Abstract

Mucormycosis is a difficult to diagnose rare disease with high morbidity and mortality. Diagnosis is often delayed, and disease tends to progress rapidly. Urgent surgical and medical intervention is lifesaving. Guidance on the complex multidisciplinary management has potential to improve prognosis, but approaches differ between health-care settings. From January, 2018, authors from 33 countries in all United Nations regions analysed the published evidence on mucormycosis management and provided consensus recommendations addressing differences between the regions of the world as part of the One World One Guideline initiative of the European Confederation of Medical Mycology (ECMM). Diagnostic management does not differ greatly between world regions. Upon suspicion of mucormycosis appropriate imaging is strongly recommended to document extent of disease and is followed by strongly recommended surgical intervention. First-line treatment with high-dose liposomal amphotericin B is strongly recommended, while intravenous isavuconazole and intravenous or delayed release tablet posaconazole are recommended with moderate strength. Both triazoles are strongly recommended salvage treatments. Amphotericin B deoxycholate is recommended against, because of substantial toxicity, but may be the only option in resource limited settings. Management of mucormycosis depends on recognising disease patterns and on early diagnosis. Limited availability of contemporary treatments burdens patients in low and middle income settings. Areas of uncertainty were identified and future research directions specified.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alastruey-Izquierdo, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arenz, DorotheeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, Sharon C. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dannaoui, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hochhegger, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoenigl, MartinUNSPECIFIEDorcid.org/0000-0002-1653-2824UNSPECIFIED
Jensen, Henrik E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lagrou, KatrienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lewis, Russell E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mellinghoff, Sibylle C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mer, MervynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pana, Zoi D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidel, DanilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sheppard, Donald C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wahba, RogerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akova, MuratUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alanio, AlexandreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Al-Hatmi, Abdullah M. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arikan-Akdagli, SevtapUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Badali, HamidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ben-Ami, RonenUNSPECIFIEDorcid.org/0000-0003-0628-0798UNSPECIFIED
Bonifaz, AlexandroUNSPECIFIEDorcid.org/0000-0003-2045-3317UNSPECIFIED
Bretagne, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castagnola, ElioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chayakulkeeree, MetheeUNSPECIFIEDorcid.org/0000-0002-4582-4914UNSPECIFIED
Colombo, Arnaldo L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corzo-Leon, Dora E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drgona, LubosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groll, Andreas H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guinea, JesusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heussel, Claus-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ibrahim, Ashraf S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kanj, Souha S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimko, NikolayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lackner, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lamoth, FredericUNSPECIFIEDorcid.org/0000-0002-1023-5597UNSPECIFIED
Lanternier, FannyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lass-Floerl, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Dong-GunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehrnbecher, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lmimouni, Badre E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mares, MihaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maschmeyer, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meis, Jacques F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meletiadis, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morrissey, C. OrlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nucci, MarcioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oladele, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pagano, LivioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pasqualotto, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patel, AtulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Racil, ZdenekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richardson, MalcolmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roilides, EmmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhnke, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seyedmousavi, SeyedmojtabaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sidharthan, NeerajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singh, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sinko, JanosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Skiada, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slavin, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soman, RajeevUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spellberg, BradUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinbach, WilliamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, Ban HockUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ullmann, Andrew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Joerg J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walsh, Thomas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
White, P. LewisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiederhold, Nathan P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zaoutis, TheoklisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chakrabarti, ArunalokeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-126110
DOI: 10.1016/S1473-3099(19)30312-3
Journal or Publication Title: Lancet Infect. Dis.
Volume: 19
Number: 12
Page Range: S. E405 - 17
Date: 2019
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1474-4457
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LIPOSOMAL AMPHOTERICIN-B; REAL-TIME PCR; INVASIVE MOLD INFECTIONS; 7-YEAR RETROSPECTIVE ANALYSIS; ORGAN TRANSPLANT RECIPIENTS; REVERSED HALO SIGN; HIGH-RISK PATIENTS; PULMONARY MUCORMYCOSIS; RENAL MUCORMYCOSIS; FUNGAL-INFECTIONSMultiple languages
Infectious DiseasesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12611

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