Universität zu Köln

Rohleder, Cathrin ORCID: 0000-0002-3559-1846, Koethe, Dagmar, Fritze, Stefan, Topor, Cristina E., Leweke, F. Markus and Hirjak, Dusan (2019). Neural correlates of binocular depth inversion illusion in antipsychotic-naive first-episode schizophrenia patients. Eur. Arch. Psych. Clin. Neurosci., 269 (8). S. 897 - 911. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-8491

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Abstract

Objectives Binocular depth inversion illusion (BDII), a visual, 'top-down'-driven information process, is impaired in schizophrenia and particularly in its early stages. BDII is a sensitive measure of impaired visual information processing and represents a valid diagnostic tool for schizophrenia and other psychotic disorders. However, neurobiological underpinnings of aberrant BDII in first-episode schizophrenia are largely unknown at present. Methods In this study, 22 right-handed, first-episode, antipsychotic-naive schizophrenia patients underwent BDII assessment and MRI scanning at 1.5 T. The surface-based analysis via new version of Freesurfer (6.0) enabled calculation of cortical thickness and surface area. BDII total and faces scores were related to the two distinct cortical measurements. Results We found a significant correlation between BDII performance and cortical thickness in the inferior frontal gyrus and middle temporal gyrus (p < 0.003, Bonferroni corr.), as well as superior parietal gyrus, postcentral gyrus, supramarginal gyrus, and precentral gyrus (p < 0.05, CWP corr.), respectively. BDII performance was significantly correlated with surface area in the superior parietal gyrus and right postcentral gyrus (p < 0.003, Bonferroni corr.). Conclusion BDII performance may be linked to cortical thickness and surface area variations in regions involved in adaptive or top-down modulation and stimulus processing, i.e., frontal and parietal lobes. Our results suggest that cortical features of distinct evolutionary and genetic origin differently contribute to BDII performance in first-episode, antipsychotic-naive schizophrenia patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rohleder, Cathrin UNSPECIFIED orcid.org/0000-0002-3559-1846 UNSPECIFIED Koethe, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Fritze, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Topor, Cristina E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leweke, F. Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Hirjak, Dusan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-126641
DOI:	10.1007/s00406-018-0886-2
Journal or Publication Title:	Eur. Arch. Psych. Clin. Neurosci.
Volume:	269
Number:	8
Page Range:	S. 897 - 911
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-8491
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FACIAL EMOTION RECOGNITION; REDUCED CORTICAL THICKNESS; SUPERIOR PARIETAL CORTEX; NEUROLOGICAL SOFT SIGNS; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; ULTRA-HIGH RISK; FUNCTIONAL CONNECTIVITY; OBJECT RECOGNITION; BIPOLAR DISORDER Multiple languages Clinical Neurology; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12664