Stein-Thoeringer, C. K., Nichols, K. B., Lazrak, A., Docampo, M. D., Slingerland, A. E., Slingerland, J. B., Clurman, A. G., Armijo, G., Gomes, A. L. C., Shono, Y., Staffas, A., da Silva, M. Burgos, Devlin, S. M., Markey, K. A., Bajic, D., Pinedo, R., Tsakmaklis, A., Littmann, E. R., Pastore, A., Taur, Y., Monette, S., Arcila, M. E., Pickard, A. J., Maloy, M., Wright, R. J., Amoretti, L. A., Fontana, E., Pham, D., Jamal, M. A., Weber, D., Sung, A. D., Hashimoto, D., Scheid, C., Xavier, J. B., Messina, J. A., Romero, K., Lew, M., Bush, A., Bohannon, L., Hayasaka, K., Hasegawa, Y., Vehreschild, M. J. G. T., Cross, J. R., Ponce, D. M., Perales, M. A., Giralt, S. A., Jenq, R. R., Teshima, T., Holler, E., Chao, N. J., Pamer, E. G., Peled, J. U. and van den Brink, M. R. M. (2019). Lactose drives Enterococcus expansion to promote graft-versus-host disease. Science, 366 (6469). S. 1143 - 1191. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

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Abstract

Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence of enterococcal expansion, which was associated with graft-versus-host disease (GVHD) and mortality. We found that Enterococcus also expands in the mouse gastrointestinal tract after allo-HCT and exacerbates disease severity in gnotobiotic models. Enterococcus growth is dependent on the disaccharide lactose, and dietary lactose depletion attenuates Enterococcus outgrowth and reduces the severity of GVHD in mice. Allo-HCT patients carrying lactose-nonabsorber genotypes showed compromised clearance of postantibiotic Enterococcus domination. We report lactose as a common nutrient that drives expansion of a commensal bacterium that exacerbates an intestinal and systemic inflammatory disease.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stein-Thoeringer, C. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nichols, K. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lazrak, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Docampo, M. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slingerland, A. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slingerland, J. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clurman, A. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Armijo, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomes, A. L. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shono, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Staffas, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
da Silva, M. BurgosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devlin, S. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Markey, K. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bajic, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinedo, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsakmaklis, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Littmann, E. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pastore, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taur, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monette, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arcila, M. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pickard, A. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maloy, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wright, R. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amoretti, L. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fontana, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pham, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jamal, M. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sung, A. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hashimoto, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheid, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xavier, J. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Messina, J. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Romero, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lew, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bush, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bohannon, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hayasaka, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasegawa, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, M. J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cross, J. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ponce, D. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perales, M. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giralt, S. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenq, R. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teshima, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holler, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chao, N. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pamer, E. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peled, J. U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Brink, M. R. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-126813
DOI: 10.1126/science.aax3760
Journal or Publication Title: Science
Volume: 366
Number: 6469
Page Range: S. 1143 - 1191
Date: 2019
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication: WASHINGTON
ISSN: 1095-9203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
VANCOMYCIN-RESISTANT ENTEROCOCCUS; CELL; MICROBIOME; BACTEREMIA; RISK; COLONIZATION; CHEMOTHERAPY; ANTIBIOTICS; COMMENSALS; DOMINATIONMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12681

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