Gonzalez Campo, Cecilia, Salamone, Paula C., Rodriguez-Arriagada, Nicolas, Richter, Fabian, Herrera, Eduar ORCID: 0000-0001-9409-245X, Bruno, Diana, Pagani Cassara, Fatima, Sinay, Vladimiro, Garcia, Adolfo M., Ibanez, Agustin and Sedeno, Lucas . Fatigue in multiple sclerosis is associated with multimodal interoceptive abnormalities. Mult. Scler. J.. LONDON: SAGE PUBLICATIONS LTD. ISSN 1477-0970
Full text not available from this repository.Abstract
Background: Fatigue ranks among the most common and disabling symptoms in multiple sclerosis (MS). Recent theoretical works have surmised that this trait might be related to alterations across interoceptive mechanisms. However, this hypothesis has not been empirically evaluated. Objectives: To determine whether fatigue in MS patients is associated with specific behavioral, structural, and functional disruptions of the interoceptive domain. Methods: Fatigue levels were established via the Modified Fatigue Impact Scale. Interoception was evaluated through a robust measure indexed by the heartbeat detection task. Structural and functional connectivity properties of key interoceptive hubs were tested by magnetic resonance imaging (MRI) and resting-state functional MRI. Machine learning analyses were employed to perform pairwise classifications. Results: Only patients with fatigue presented with decreased interoceptive accuracy alongside decreased gray matter volume and increased functional connectivity in core interoceptive regions, the insula, and the anterior cingulate cortex. Each of these alterations was positively associated with fatigue. Finally, machine-learning analysis with a combination of the above interoceptive indices (behavioral, structural, and functional) successfully discriminated (area under the curve > 90%) fatigued patients from both non-fatigued and healthy controls. Conclusion: This study offers unprecedented evidence suggesting that disruptions of neurocognitive markers subserving interoception may constitute a signature of fatigue in MS.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||
Creators: |
|
||||||||||||||||||||||||||||||||||||||||||||||||
URN: | urn:nbn:de:hbz:38-126939 | ||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1177/1352458519888881 | ||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Mult. Scler. J. | ||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | SAGE PUBLICATIONS LTD | ||||||||||||||||||||||||||||||||||||||||||||||||
Place of Publication: | LONDON | ||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1477-0970 | ||||||||||||||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||
Uncontrolled Keywords: |
|
||||||||||||||||||||||||||||||||||||||||||||||||
Refereed: | Yes | ||||||||||||||||||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/12693 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
View Item |