Universität zu Köln

Weise, Friederike, Vieth, Michael, Reinhold, Dirk, Haybaeck, Johannes, Goni, Elisabetta, Lippert, Hans, Ridwelski, Karsten, Lingohr, Philipp, Schildberg, Claus, Vassos, Nikolaos, Kruschewski, Martin, Krasniuk, Iurii, Grimminger, Peter P., Waidmann, Oliver, Peitz, Ulrich, Veits, Lothar, Kreuser, Nicole, Lang, Hauke, Bruns, Christiane, Moehler, Markus, Lordick, Florian, Gockel, Ines, Schumacher, Johannes, Malfertheiner, Peter and Venerito, Marino ORCID: 0000-0001-8581-0974 (2020). Gastric cancer in autoimmune gastritis: A case-control study from the German centers of the staR project on gastric cancer research. United European Gastroenterol. J., 8 (2). S. 175 - 185. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 2050-6414

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Abstract

Objectives Patients with autoimmune gastritis (AIG) are reported to have an increased risk of developing gastric cancer (GC). In this study, we assess the characteristics and outcomes of GC patients with AIG in a multicenter case-control study. Methods Between April 2013 and May 2017, patients with GC, including cancers of the esophagogastric junction (EGJ) Siewert type II and III, were recruited. Patients with histological characteristics of AIG were identified and matched in a 1:2 fashion for age and gender to GC patients with no AIG. Presenting symptoms were documented using a self-administered questionnaire. Results Histological assessment of gastric mucosa was available for 572/759 GC patients. Overall, 28 (4.9%) of GC patients had AIG (67 +/- 9 years, female-to-male ratio 1.3:1). In patients with AIG, GC was more likely to be localized in the proximal (i.e. EGJ, fundus, corpus) stomach (odds ratio (OR) 2.7, 95% confidence interval (CI) 1.0-7.1). In GC patients with AIG, pernicious anemia was the leading clinical sign (OR 22.0, 95% CI 2.6-187.2), and the most common indication for esophagogastroduodenoscopy (OR 29.0, 95% CI 7.2-116.4). GC patients with AIG were more likely to present without distant metastases (OR 6.2, 95% CI 1.3-28.8) and to be treated with curative intention (OR 3.0, 95% CI 1.0-9.0). The five-year survival rates with 95% CI in GC patients with and with no AIG were 84.7% (83.8-85.6) and 53.5% (50.9-56.1), respectively (OR 0.25, 95% CI 0.08-0.75, p = 0.001). Conclusions Pernicious anemia leads to earlier diagnosis of GC in AIG patients and contributes significantly to a better clinical outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weise, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Vieth, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinhold, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Haybaeck, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Goni, Elisabetta UNSPECIFIED UNSPECIFIED UNSPECIFIED Lippert, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Ridwelski, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Lingohr, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildberg, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Vassos, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Kruschewski, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Krasniuk, Iurii UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimminger, Peter P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Waidmann, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Peitz, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Veits, Lothar UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuser, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Hauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Moehler, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Lordick, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Gockel, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Malfertheiner, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Venerito, Marino UNSPECIFIED orcid.org/0000-0001-8581-0974 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-127138
DOI:	10.1177/2050640619891580
Journal or Publication Title:	United European Gastroenterol. J.
Volume:	8
Number:	2
Page Range:	S. 175 - 185
Date:	2020
Publisher:	SAGE PUBLICATIONS INC
Place of Publication:	THOUSAND OAKS
ISSN:	2050-6414
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PARIETAL-CELL ANTIBODIES; HELICOBACTER-PYLORI; ATROPHIC GASTRITIS; PERNICIOUS-ANEMIA; CLASSIFICATION; PATHOGENESIS Multiple languages Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12713