Zhou, Chenhao ORCID: 0000-0002-4800-3249, Wang, Shun, Zhou, Qiang, Zhao, Jin, Xia, Xianghou, Chen, Wanyong, Zheng, Yan, Xue, Min, Yang, Feng, Fu, Deliang, Yin, Yirui, Atyah, Manar, Qin, Lunxiu, Zhao, Yue, Bruns, Christiane, Jia, Huliang, Ren, Ning ORCID: 0000-0001-9776-2471 and Dong, Qiongzhu (2019). A Long Non-coding RNA Signature to Improve Prognostic Prediction of Pancreatic Ductal Adenocarcinoma. Front. Oncol., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2234-943X

Full text not available from this repository.

Abstract

Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive solid malignant tumors worldwide. Increasing investigations demonstrate that long non-coding RNAs (lncRNAs) expression is abnormally dysregulated in cancers. It is crucial to identify and predict the prognosis of patients for the selection of further therapeutic treatment. Methods: PDAC lncRNAs abundance profiles were used to establish a signature that could better predict the prognosis of PDAC patients. The least absolute shrinkage and selection operator (LASSO) Cox regression model was applied to establish a multi-lncRNA signature in the TCGA training cohort (N = 107). The signature was then validated in a TCGA validation cohort (N = 70) and another independent Fudan cohort (N = 46). Results: A five-lncRNA signature was constructed and it was significantly related to the overall survival (OS), either in the training or validation cohorts. Through the subgroup and Cox regression analyses, the signature was proven to be independent of other clinic-pathologic parameters. Receiver operating characteristic curve (ROC) analysis also indicated that our signature had a better predictive capacity of PDAC prognosis. Furthermore, ClueGO and CluePedia analyses showed that a number of cancer-related and drug response pathways were enriched in high risk groups. Conclusions: Identifying the five-lncRNA signature (RP11-159F24.5, RP11-744N12.2, RP11-388M20.1, RP11-356C4.5, CTC-459F4.9) may provide insight into personalized prognosis prediction and new therapies for PDAC patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zhou, ChenhaoUNSPECIFIEDorcid.org/0000-0002-4800-3249UNSPECIFIED
Wang, ShunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhou, QiangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhao, JinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xia, XianghouUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, WanyongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zheng, YanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xue, MinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, FengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fu, DeliangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yin, YiruiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Atyah, ManarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Qin, LunxiuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhao, YueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruns, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jia, HuliangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ren, NingUNSPECIFIEDorcid.org/0000-0001-9776-2471UNSPECIFIED
Dong, QiongzhuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-127924
DOI: 10.3389/fonc.2019.01160
Journal or Publication Title: Front. Oncol.
Volume: 9
Date: 2019
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 2234-943X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COLORECTAL-CANCER; SURVIVAL; IDENTIFICATION; BIOLOGY; GENOME; GRADEMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12792

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item