Universität zu Köln

Rabenstein, Monika, Unverricht-Yeboah, Marcus, Keuters, Meike Hedwig, Pikhovych, Anton, Hucklenbroich, Joerg, Vay, Sabine Ulrike, Blaschke, Stefan, Ladwig, Anne, Walter, Helene Luise, Beiderbeck, Magdalena, Fink, Gereon Rudolf, Schroeter, Michael, Kriehuber, Ralf and Rueger, Maria Adele (2019). Transcranial Current Stimulation Alters the Expression of Immune-Mediating Genes. Front. Cell. Neurosci., 13. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5102

Full text not available from this repository.

Abstract

Despite its extensive use in clinical studies, the molecular mechanisms underlying the effects of transcranial direct current stimulation (tDCS) remain to be elucidated. We previously described subacute effects of tDCS on immune- and stem cells in the rat brain. To investigate the more immediate effects of tDCS regulating those cellular responses, we treated rats with a single session of either anodal or cathodal tDCS, and analyzed the gene expression by microarray; sham-stimulated rats served as control. Anodal tDCS increased expression of several genes coding for the major histocompatibility complex I (MHC I), while cathodal tDCS increased the expression of the immunoregulatory protein osteopontin (OPN). We confirmed the effects of gene upregulation by immunohistochemistry at the protein level. Thus, our data show a novel mechanism for the actions of tDCS on immune- and inflammatory processes, providing a target for future therapeutic studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rabenstein, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Unverricht-Yeboah, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Keuters, Meike Hedwig UNSPECIFIED UNSPECIFIED UNSPECIFIED Pikhovych, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Hucklenbroich, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Vay, Sabine Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Blaschke, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ladwig, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, Helene Luise UNSPECIFIED UNSPECIFIED UNSPECIFIED Beiderbeck, Magdalena UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kriehuber, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueger, Maria Adele UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130332
DOI:	10.3389/fncel.2019.00461
Journal or Publication Title:	Front. Cell. Neurosci.
Volume:	13
Date:	2019
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5102
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MHC CLASS-I; CENTRAL-NERVOUS-SYSTEM; HUMAN MOTOR CORTEX; NEURAL STEM-CELLS; SYNAPTIC PLASTICITY; CEREBRAL-CORTEX; OSTEOPONTIN; RAT; INDUCTION; INFLAMMATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13033