Universität zu Köln

Rangaraju, Vidhya ORCID: 0000-0002-6716-4312, Lewis, Tommy L., Jr., Hirabayashi, Yusuke, Bergami, Matteo ORCID: 0000-0001-5525-5025, Motori, Elisa, Cartoni, Romain ORCID: 0000-0001-9138-9135, Kwon, Seok-Kyu ORCID: 0000-0002-7280-9867 and Courchet, Julien (2019). Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease. J. Neurosci., 39 (42). S. 8200 - 8209. WASHINGTON: SOC NEUROSCIENCE. ISSN 1529-2401

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Abstract

Mitochondria play many important biological roles, including ATP production, lipid biogenesis, ROS regulation, and calcium clearance. In neurons, the mitochondrion is an essential organelle for metabolism and calcium homeostasis. Moreover, mitochondria are extremely dynamic and able to divide, fuse, and move along microtubule tracks to ensure their distribution to the neuronal periphery. Mitochondrial dysfunction and altered mitochondrial dynamics are observed in a wide range of conditions, from impaired neuronal development to various neurodegenerative diseases. Novel imaging techniques and genetic tools provide unprecedented access to the physiological roles of mitochondria by visualizing mitochondrial trafficking, morphological dynamics, ATP generation, and ultrastructure. Recent studies using these new techniques have unveiled the influence of mitochondria on axon branching, synaptic function, calcium regulation with the ER, glial cell function, neurogenesis, and neuronal repair. This review provides an overview of the crucial roles played by mitochondria in the CNS in physiological and pathophysiological conditions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rangaraju, Vidhya UNSPECIFIED orcid.org/0000-0002-6716-4312 UNSPECIFIED Lewis, Tommy L., Jr. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hirabayashi, Yusuke UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergami, Matteo UNSPECIFIED orcid.org/0000-0001-5525-5025 UNSPECIFIED Motori, Elisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Cartoni, Romain UNSPECIFIED orcid.org/0000-0001-9138-9135 UNSPECIFIED Kwon, Seok-Kyu UNSPECIFIED orcid.org/0000-0002-7280-9867 UNSPECIFIED Courchet, Julien UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130790
DOI:	10.1523/JNEUROSCI.1157-19.2019
Journal or Publication Title:	J. Neurosci.
Volume:	39
Number:	42
Page Range:	S. 8200 - 8209
Date:	2019
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	1529-2401
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRAIN ENERGY-METABOLISM; ENDOPLASMIC-RETICULUM; AXONAL MITOCHONDRIA; DIFFERENTIAL DISTRIBUTION; AEROBIC GLYCOLYSIS; LOCAL TRANSLATION; DENDRITIC SPINES; CRITICAL PERIOD; MESSENGER-RNAS; ATP SYNTHESIS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13079