Nabieva, Naiba, Haeberle, Lothar, Brucker, Sara Y., Janni, Wolfgang, Volz, Bernhard, Loehberg, Christian R., Hartkopf, Andreas D., Walter, Christina-Barbara, Baake, Gerold, Fridman, Alexander, Malter, Wolfram, Wuerstlein, Rachel, Harbeck, Nadia, Hoffmann, Oliver, Kuemmel, Sherko, Martin, Bernhard, Thomssen, Christoph, Graf, Heiko, Wolf, Christopher, Lux, Michael P., Bayer, Christian M., Rauh, Claudia, Hack, Carotin C., Almstedt, Katrin, Gass, Paul, Heindl, Felix ORCID: 0000-0002-5484-2575, Brodkorb, Tobias, Lindner, Christoph, Kolberg, Hans-Christian, Krabisch, Petra, Weigel, Michael, Steinfeld-Birg, Dieter, Kohls, Andreas, Brucker, Cosima, Schulz, Volker, Fischer, Gunnar, Pelzer, Volker, Rack, Brigitte, Beckmann, Matthias W., Fehm, Tanja, Rody, Achim, Maass, Nicolai, Hein, Alexander ORCID: 0000-0003-2601-3398 and Fasching, Peter A. (2019). Preexisting musculoskeletal burden and its development under letrozole treatment in early breast cancer patients. Int. J. Cancer, 145 (8). S. 2114 - 2122. HOBOKEN: WILEY. ISSN 1097-0215

Full text not available from this repository.

Abstract

One of the most common adverse events (AEs) occurring during treatment with aromatase inhibitors (AIs) is musculoskeletal pain. The aim of our study was to analyze the influence of preexisting muscle/limb pain and joint pain on the development of AI-induced musculoskeletal AEs. Women eligible for upfront adjuvant endocrine therapy with letrozole were included in the PreFace study, a multicenter phase IV trial. During the first treatment year, they were asked to record musculoskeletal AEs monthly by answering questions regarding pain symptoms and rating the pain intensity on a numeric rating scale from 0 (no pain) to 10 (very strong pain). Pain values were compared using nonparametric statistical tests. Overall, 1,416 patients were evaluable. The average pain value over all time points in women with preexisting muscle/limb pain was 4.3 (median 4.3); in those without preexisting pain, it was 2.0 (median 1.7). In patients without preexisting muscle/limb pain, pain levels increased relatively strongly within the first 6 months (mean increase +0.9, p < 0.00001) in comparison with those with preexisting pain (mean increase +0.3, p < 0.001), resulting in a statistically significant difference (p < 0.00001) between the two groups. The development of joint pain was similar in the two groups. Women without preexisting muscle/limb pain or joint pain have the greatest increase in pain after the start of adjuvant AI therapy. Women with preexisting pain have significantly higher pain values. The main increase in pain values takes place during the first 6 months of treatment.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Nabieva, NaibaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haeberle, LotharUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brucker, Sara Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janni, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volz, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loehberg, Christian R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartkopf, Andreas D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walter, Christina-BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baake, GeroldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fridman, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malter, WolframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuerstlein, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harbeck, NadiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuemmel, SherkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomssen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graf, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lux, Michael P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayer, Christian M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauh, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hack, Carotin C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Almstedt, KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gass, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heindl, FelixUNSPECIFIEDorcid.org/0000-0002-5484-2575UNSPECIFIED
Brodkorb, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindner, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kolberg, Hans-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krabisch, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weigel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinfeld-Birg, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohls, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brucker, CosimaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, GunnarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pelzer, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rack, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beckmann, Matthias W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fehm, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rody, AchimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maass, NicolaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hein, AlexanderUNSPECIFIEDorcid.org/0000-0003-2601-3398UNSPECIFIED
Fasching, Peter A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-130915
DOI: 10.1002/ijc.32294
Journal or Publication Title: Int. J. Cancer
Volume: 145
Number: 8
Page Range: S. 2114 - 2122
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1097-0215
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
JOINT SYMPTOMS; POSTMENOPAUSAL WOMEN; AROMATASE INHIBITORS; FREE SURVIVAL; RISK-FACTORS; TAMOXIFEN; TRIAL; ANASTROZOLE; ARTHRALGIA; THERAPYMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13091

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item