Putensen, C., Ellger, B., Sakka, S. G., Weyland, A., Schmidt, K., Zoller, M., Weiler, N., Kindgen-Milles, D., Jaschinski, U., Weile, J., Lindau, S., Kieninger, M., Faltlhauser, A., Jung, N., Teschendorf, P., Adamzik, M., Gruendling, M., Wahlers, T., Gerlach, H. and Litty, F. -A. (2019). Current clinical use of intravenous fosfomycin in ICU patients in two European countries. Infection, 47 (5). S. 827 - 837. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

Full text not available from this repository.

Abstract

Purpose In Europe, intravenous fosfomycin (IV) is used particularly in difficult-to- treat or complex infections, caused by both Gram-positive and Gram-negative pathogens including multidrug-resistant strains. Here, we investigated the efficacy and safety of intravenous fosfomycin under real-life conditions. Methods Prospective, multi-center, and non-interventional study in patients with bacterial infections from 20 intensive care units (ICU) in Germany and Austria (NCT01173575). Results Overall, 209 patients were included (77 females, 132 males, mean age: 59 +/- 16 years), 194 of which were treated in intensive care (APACHE II score at the beginning of fosfomycin therapy: 23 +/- 8). Main indications (+/- bacteremia or sepsis) were infections of the CNS (21.5%), community- (CAP) and hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP, 15.3%), bone and joint infections (BJI, 11%), abdominal infections (11%), and bacteremia (10.5%). Most frequently identified pathogens were S. aureus (22.3%), S. epidermidis (14.2%), Enterococcus spp. (10.8%), E. coli (12.3%) and Klebsiella spp. (7.7%). At least one multidrug-resistant (MDR) pathogen was isolated from 51 patients (24.4%). Fosfomycin was administered with an average daily dose of 13.7 +/- 3.5 g over 12.4 +/- 8.6 days, almost exclusively (99%) in combination with other antibiotics. The overall clinical success was favorable in 81.3% (148/182) of cases, and in 84.8% (39/46) of patients with >= 1 MDR pathogen. Noteworthy, 16.3% (34/209) of patients developed at least one, in the majority of cases non-serious, adverse drug reaction during fosfomycin therapy. Conclusion Our data suggest that IV fosfomycin is an effective and safe combination partner for the treatment of a broad spectrum of severe bacterial infections in critically ill patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Putensen, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ellger, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sakka, S. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weyland, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zoller, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiler, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kindgen-Milles, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaschinski, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weile, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindau, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kieninger, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faltlhauser, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jung, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teschendorf, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adamzik, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruendling, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wahlers, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerlach, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Litty, F. -A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-131641
DOI: 10.1007/s15010-019-01323-4
Journal or Publication Title: Infection
Volume: 47
Number: 5
Page Range: S. 827 - 837
Date: 2019
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1439-0973
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTENSIVE-CARE-UNIT; MULTIDRUG-RESISTANT; CEREBROSPINAL-FLUID; ESCHERICHIA-COLI; STAPHYLOCOCCUS-AUREUS; KLEBSIELLA-PNEUMONIAE; INFECTIONS; CARBAPENEMS; TIGECYCLINE; EFFICACYMultiple languages
Infectious DiseasesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13164

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item