Universität zu Köln

Telschow, Anna, Ferrari, Nina, Deibert, Clara, Floeck, Anne, Merz, Waltraut M., Gembruch, Ulrich ORCID: 0000-0001-8284-4669, Ehrhardt, Christina, Doetsch, Joerg and Graf, Christine (2019). High Maternal and Low Cord Blood Leptin Are Associated with BMI-SDS Gain in the First Year of Life. Obes. Facts, 12 (5). S. 575 - 586. BASEL: KARGER. ISSN 1662-4033

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Abstract

Background: Early infant weight development influences metabolic regulation later in life. For the prevention of obesity and metabolic diseases, it is important to understand the underlying mechanisms in detail. Objectives: This study aims to examine the effects of maternal anthropometric, sociodemographic, and lifestyle factors on maternal and cord blood leptin levels at birth and on the development of body mass index (BMI) standard deviation scores (SDS) in offspring up to 1 year of age. Methods: Seventy-six mother-child pairs were enrolled in this follow-up analysis in a cross-sectional design. Standardized questionnaires were used to collect information regarding maternal anthropometrics, lifestyle habits, and sociodemographic conditions, and newborn weight, or, rather, BMI-SDS, development during the first year of life. Results: Cord blood leptin (beta = -0.222, p = 0.074), maternal leptin (beta = 0.414, p = 0.001), and female sex of the offspring (beta = 0.385, p = 0.003) explained 29.0% of the variance in BMI-SDS changes in the first year of life. Cord blood leptin was influenced by newborn sex (male; beta = -0.220, p = 0.025) and maternal moderate-intensity physical activity in the third trimester (beta = 0.265, p = 0.007, corr. R-2 = 9.2%); maternal leptin was influenced by maternal prepregnancy BMI (beta = 0.602, p < 0.001) and weight gain during pregnancy (beta = 0.247, p = 0.004, corr. R-2 = 35.5%). Conclusions: Higher maternal and lower cord blood leptin levels are associated with a higher BMI-SDS increase during the first year of life. Maternal leptin is influenced by maternal BMI and weight gain during pregnancy, and cord blood leptin is influenced by maternal physical activity; therefore, it can be suggested that an active and healthy maternal lifestyle may play a pivotal and beneficial role in the offspring's weight development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Telschow, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferrari, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Deibert, Clara UNSPECIFIED UNSPECIFIED UNSPECIFIED Floeck, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Merz, Waltraut M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED Ehrhardt, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Graf, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-132051
DOI:	10.1159/000502421
Journal or Publication Title:	Obes. Facts
Volume:	12
Number:	5
Page Range:	S. 575 - 586
Date:	2019
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1662-4033
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEASURING PHYSICAL-ACTIVITY; BODY-MASS INDEX; METABOLIC RISK; WEIGHT-GAIN; ADIPOSITY; CHILDHOOD; OVERWEIGHT; PREGNANCY; CHILDREN; OBESITY Multiple languages Endocrinology & Metabolism; Nutrition & Dietetics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13205