Universität zu Köln

Bauer, D., Kasper, M., Walscheid, K., Koch, J. M., Muether, P. S., Kirchhof, B., Heiligenhaus, A. and Heinz, C. (2020). Alteration of MCP-1 and MMP-9 in aqueous humor is associated with secondary glaucoma in Fuchs uveitis syndrome. Ocul. Immunol. Inflamm., 28 (4). S. 688 - 699. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1744-5078

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Abstract

Purpose: To analyze changes in concentrations of pro- or anti-inflammatory cytokines, chemokines, or metalloproteinases (MMP) in the aqueous humor (AH) in Fuchs uveitis syndrome (FUS) patients with (FUSwG) or without (FUSwoG) secondary glaucoma. Methods: AH samples were collected from 43 eyes of Caucasian subjects (FUSwoG: n = 11; FUSwG: n = 8; control eyes: n = 24). Concentrations of IL-8, MCP-1, MMP-1,-2,-3,-9, SAA, TGF ss-1,-2,-3, and TNF-alpha were measured by multiplex bead assay analysis. Results: Compared with the control group, levels of IL-8, MCP-1, MMP-3, and MMP-9 in the AH were significantly increased in FUSwG and FUSwoG patients. In contrast to FUSwoG patients, MCP-1 and MMP-9 level were lower in FUSwG, while expression of MMP-2, MMP-3, and TGF beta-1 was increased. Conclusion: In our experiments, glaucoma in FUS patients was associated with low levels of MCP-1 and MMP-9 in the AH, while expression of MMP-2, MMP-3, and TGF beta-1 increased. The alteration in these molecular patterns may contribute to the development of glaucoma in FUS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bauer, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kasper, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walscheid, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Muether, P. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heiligenhaus, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinz, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-135486
DOI:	10.1080/09273948.2019.1609049
Journal or Publication Title:	Ocul. Immunol. Inflamm.
Volume:	28
Number:	4
Page Range:	S. 688 - 699
Date:	2020
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1744-5078
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN TRABECULAR MESHWORK; GROWTH-FACTOR-BETA; OPEN-ANGLE GLAUCOMA; RUBELLA-VIRUS; HETEROCHROMIC IRIDOCYCLITIS; MATRIX METALLOPROTEINASES; CLINICAL-FEATURES; TISSUE INHIBITORS; EXPRESSION; TGF-BETA-1 Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13548