Universität zu Köln

Nikopoulou, Chrysa, Parekh, Swati and Tessarz, Peter (2019). Ageing and sources of transcriptional heterogeneity. Biol. Chem., 400 (7). S. 867 - 879. BERLIN: WALTER DE GRUYTER GMBH. ISSN 1437-4315

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Abstract

Cellular heterogeneity is an important contributor to biological function and is employed by cells, tissues and organisms to adapt, compensate, respond, defend and/or regulate specific processes. Research over the last decades has revealed that transcriptional noise is a major driver for cell-to-cell variability. In this review we will discuss sources of transcriptional variability, in particular bursting of gene expression and how it could contribute to cellular states and fate decisions. We will highlight recent developments in single cell sequencing technologies that make it possible to address cellular heterogeneity in unprecedented detail. Finally, we will review recent literature, in which these new technologies are harnessed to address pressing questions in the field of ageing research, such as transcriptional noise and cellular heterogeneity in the course of ageing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nikopoulou, Chrysa UNSPECIFIED UNSPECIFIED UNSPECIFIED Parekh, Swati UNSPECIFIED UNSPECIFIED UNSPECIFIED Tessarz, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-137006
DOI:	10.1515/hsz-2018-0449
Journal or Publication Title:	Biol. Chem.
Volume:	400
Number:	7
Page Range:	S. 867 - 879
Date:	2019
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	1437-4315
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STOCHASTIC GENE-EXPRESSION; NF-KAPPA-B; CHROMATIN ACCESSIBILITY; MONOALLELIC EXPRESSION; CENTRAL DOGMA; DNA-BINDING; REVEALS; SUBPOPULATIONS; VARIABILITY; ACTIVATION Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13700