Universität zu Köln

Hagmeyer, Lars, Theegarten, Dirk, Wohlschlaeger, Jeremias, Hager, Thomas, Treml, Marcel, Herkenrath, Simon Dominik, Hekmat, Khosro, Heldwein, Matthias and Randerath, Winfried J. (2019). Transbronchial cryobiopsy in fibrosing interstitial lung disease: modifications of the procedure lead to risk reduction. Thorax, 74 (7). S. 711 - 715. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-3296

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Abstract

Sixty-one subjects with fibrosing interstitial lung disease were prospectively analysed to determine the efficacy of transbronchial cryobiopsy (CryoTBB) and the effect of procedural modifications which were introduced after an interim analysis of the first 19 subjects. The modifications significantly reduced complication rates from 84% to 14% (p<0.001). 30-day-mortality was 2%. The algorithm with initial CryoTBB and surgical lung biopsy (SLB) as optional step-up procedure was feasible. CryoTBB led to a confident diagnosis in 46/61 subjects (75%). Only 21% out of all subjects were forwarded for SLB. As the modified CryoTBB reduced but not eliminated the risk of severe complications, tissue sampling should be limited to patients where confident diagnosis enables life prolonging therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hagmeyer, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Theegarten, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlschlaeger, Jeremias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hager, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Treml, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Herkenrath, Simon Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Hekmat, Khosro UNSPECIFIED UNSPECIFIED UNSPECIFIED Heldwein, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Randerath, Winfried J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-137087
DOI:	10.1136/thoraxjnl-2018-212095
Journal or Publication Title:	Thorax
Volume:	74
Number:	7
Page Range:	S. 711 - 715
Date:	2019
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-3296
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IDIOPATHIC PULMONARY-FIBROSIS; DIAGNOSIS; SAFETY; STATEMENT; BIOPSY Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13708