Universität zu Köln

Weckx, Annelies, Riekert, Maximilian, Grandoch, Andrea, Schick, Volker, Zoeller, Joachim E. and Kreppel, Matthias (2019). Time to recurrence and patient survival in recurrent oral squamous cell carcinoma. Oral Oncol., 94. S. 8 - 14. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1879-0593

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Abstract

Objectives: Tumour relapse remains one of the major problems in managing oral squamous cell carcinoma (OSCC) with mortality rates of up to 92%. Early recurrences have a worse prognosis than late relapses. However, few has been written about the influence of clinicopathological parameters on the timing of recurrence and the patient survival. Materials and methods: Retrospective chart review of 159 patients with an OSCC recurrent disease. Exclusion criteria were neoadjuvant chemoradiotherapy, follow-up < 6 weeks, perioperative death, second primaries and inadequate information on clinicopathological parameters. Statistical analysis was performed using univariate and multivariate analysis. Results: A significant correlation was found in the chi 2-analysis between the timing of recurrence and the margin status (p = 0.020), lymph node ratio (p = 0.030) and grading (p = 0.003) of the primary tumour. In the multivariate survival analysis, the timing of recurrence (p < 0.001), margin status of the primary tumour (p = 0.023), presence of extracapsular spread in the primary tumour (p = 0.003) and performance of a salvage treatment (p < 0.001) were shown to be independent risk factors for overall survival. Conclusion: For patients with a recurrent OSCC, the time to recurrence, margin status, extracapsular spread and the performance of a salvage treatment are independent prognostic factors for overall survival. Furthermore, a significant association exists between the moment of recurrence and the lymph node ratio, the margin status and grading of the primary tumour. This knowledge can allow for the development of individualised surveillance programs and like this, an earlier diagnosis and better second treatment chance in the case of a recurrence.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weckx, Annelies UNSPECIFIED UNSPECIFIED UNSPECIFIED Riekert, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Grandoch, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Schick, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-137116
DOI:	10.1016/j.oraloncology.2019.05.002
Journal or Publication Title:	Oral Oncol.
Volume:	94
Page Range:	S. 8 - 14
Date:	2019
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1879-0593
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CLINICOPATHOLOGICAL RISK-FACTORS; LOCOREGIONAL RECURRENCE; RETROSPECTIVE ANALYSIS; EXTRACAPSULAR SPREAD; LOCAL RECURRENCE; NECK RECURRENCE; HEAD; CAVITY; SURGERY; DISSECTION Multiple languages Oncology; Dentistry, Oral Surgery & Medicine Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13711