Baues, Christian, Goergen, Helen, Semrau, Robert, Nast-Kolb, Beatrix, Assenmacher, Katja, Celik, Eren, Morgenthaler, Janis, Rosenbrock, Johannes, Trommer-Nestler, Maike, Houbois, Christian, Kobe, Carsten, Kriz, Jan, Engert, Andreas and Marnitz, Simone (2019). Volumetric assessment of mediastinal lymphoma masses in Hodgkin lymphoma. Leuk. Lymphoma, 60 (13). S. 3244 - 3251. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403

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Abstract

The large mediastinal mass (LMM) at initial staging represents a risk factor in Hodgkin lymphoma (HL) and is measured by X-ray. Depending on location of the LMM, different results can occur regardless of the initial lymphoma volume. To assess this risk factor more accurately, we evaluated the method of volumetry in 77 patients of HD13/14 study of the German Hodgkin Study Group. Furthermore, volume calculations based on three or only one diameter, were performed to simplify volume assessment. Inter-rater reliability was good for all methods. The 3-diameter measurement produced larger volumes than volumetric assessment with an intraclass correlation coefficient (ICC) of 0.93, which could be improved to 0.95 by multiplying volumes with a correction factor of 0.86. The 1-dimensional measurement strongly overestimated the volume with an ICC of 0.7. In conclusion, the simplified volume estimation based on 3 largest diameters provides a reliable concept for the staging of HL patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Baues, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goergen, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Semrau, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nast-Kolb, BeatrixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Assenmacher, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Celik, ErenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morgenthaler, JanisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenbrock, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trommer-Nestler, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houbois, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobe, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kriz, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engert, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marnitz, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-137495
DOI: 10.1080/10428194.2019.1623888
Journal or Publication Title: Leuk. Lymphoma
Volume: 60
Number: 13
Page Range: S. 3244 - 3251
Date: 2019
Publisher: TAYLOR & FRANCIS LTD
Place of Publication: ABINGDON
ISSN: 1029-2403
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TUMOR BURDEN; PROGNOSTIC-FACTORS; OPEN-LABEL; DISEASE; TOMOGRAPHY; TRIAL; ABVDMultiple languages
Oncology; HematologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13749

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