Roedel, Franz, Martin, Daniel ORCID: 0000-0002-8674-2683, Balermpas, Panagiotis ORCID: 0000-0001-5261-6446, Wieland, Ulrike, Winkelmann, Ria, Riekmann, Thorsten, Falk, Stephan, Roedel, Claus and Fokas, Emmanouil (2019). Modulation of radiation sensitivity and antitumor immunity by viral pathogenic factors: Implications for radio-immunotherapy. Biochim. Biophys. Acta-Rev. Cancer, 1871 (1). S. 126 - 138. AMSTERDAM: ELSEVIER. ISSN 1879-2561

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Abstract

Several DNA viruses including Human Papillomavirus (HPV), Epstein-Barr virus (EBV), and Human cytomegalovirus (HCMV) are mechanistically associated with the development of human cancers (HPV, EBV) and/or modulation of the immune system (HCMV). Moreover, a number of distinct mechanisms have been described regarding the modulation of tumor cell response to ionizing radiation and evasion from the host immune system by viral factors. There is further accumulating interest in the treatment with immune-modulatory therapies such as immune checkpoint inhibitors for malignancies with a viral etiology. Also, patients with HPV-positive tumors have a significantly improved prognosis that is attributable to increased intrinsic radiation sensitivity and may also arise from modulation of a cytotoxic T cell response in the tumor microenvironment (TME). In this review, we will highlight recent advances in the understanding of the biological basis of radiation response mediated by viral pathogenic factors and evasion from and modulation of the immune system by viruses.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Roedel, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, DanielUNSPECIFIEDorcid.org/0000-0002-8674-2683UNSPECIFIED
Balermpas, PanagiotisUNSPECIFIEDorcid.org/0000-0001-5261-6446UNSPECIFIED
Wieland, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winkelmann, RiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riekmann, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falk, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roedel, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fokas, EmmanouilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-139180
DOI: 10.1016/j.bbcan.2018.12.006
Journal or Publication Title: Biochim. Biophys. Acta-Rev. Cancer
Volume: 1871
Number: 1
Page Range: S. 126 - 138
Date: 2019
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1879-2561
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EPSTEIN-BARR-VIRUS; SQUAMOUS-CELL CARCINOMA; TUMOR-INFILTRATING LYMPHOCYTES; PAPILLOMAVIRUS-POSITIVE HEAD; STRAND BREAK REPAIR; HPV-ASSOCIATED HEAD; NASOPHARYNGEAL CARCINOMA; HUMAN CYTOMEGALOVIRUS; NECK-CANCER; CHECKPOINT BLOCKADEMultiple languages
Biochemistry & Molecular Biology; Biophysics; OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/13918

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