Universität zu Köln

Huebel, Kai, Ostermann, H., Glass, Bertram, Noppeney, Richard, Kron, Florian, Kron, Anna, Milkovich, Gary and Mohty, Mohamad (2019). Plerixafor in non-Hodgkin's lymphoma patients: a German analysis of time, effort and costs. Bone Marrow Transplant., 54 (1). S. 123 - 130. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

Mobilization and collection of peripheral blood stem cells is part of the standard treatment procedure for non-Hodgkin's lymphoma patients eligible for high-dose chemotherapy with autologous stem cell transplantation. Mobilization is usually achieved with chemotherapy and/or cytokines, but plerixafor might be added in case of poor mobilization. Due to the high cost several institutions have developed their own management pathway to optimize use of plerixafor. Such models are however rarely generalizable; in a multi-center, European, non-interventional study, evaluating the impact of plerixafor in poor mobilizers, country specific differences in patient treatment and cost structure were obvious. For German centers, there was a non-significant reduction in the number of apheresis sessions carried out and in apheresis costs. In contrast to other European countries the majority of German Plerixafor patients were very poor mobilizing patients with initial CD34+ cell count <= 10/mu l (40/51). In this group the number of apheresis sessions decreased from 2.1 to 1.6 sessions per patient (p = 0.01) and costs decreased from (sic)6246 to (sic)4758 (p = 0.01). Our results show that preemptive plerixafor use has a strong effect in poor mobilizers with an initial CD34+ cell count <= 10 cells/mu l.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Huebel, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Ostermann, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Glass, Bertram UNSPECIFIED UNSPECIFIED UNSPECIFIED Noppeney, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Kron, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kron, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Milkovich, Gary UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohty, Mohamad UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140296
DOI:	10.1038/s41409-018-0228-z
Journal or Publication Title:	Bone Marrow Transplant.
Volume:	54
Number:	1
Page Range:	S. 123 - 130
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL MOBILIZATION; MULTIPLE-MYELOMA; POOR MOBILIZATION; BLOOD; RISK; TRANSPLANTATION; STRATEGIES; CHEMOTHERAPY; COLLECTION; ALGORITHM Multiple languages Biophysics; Oncology; Hematology; Immunology; Transplantation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14029