Ebert, Anne-Karoline, Zwink, Nadine, Jenetzky, Ekkehart ORCID: 0000-0001-5415-8784, Stein, Raimund, Boemers, Thomas M., Lacher, Martin, Fortmann, Caroline, Obermayr, Florian, Fisch, Margit, Mortazawi, Kiarasch, Schmiedeke, Eberhard, Eisenschmidt, Volker, Schaefer, Mattias, Hirsch, Karin, Roesch, Wolfgang H. and Reutter, Heiko (2019). Association Between Exstrophy-epispadias Complex And Congenital Anomalies: A German Multicenter Study. Urology, 123. S. 210 - 220. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1527-9995

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Abstract

OBJECTIVE To further investigate associated anomalies in exstrophy-epispadias complex (EEC) patients con- genital uro-rectal malformations network (CURE-Net) database was systematically screened. In literature the EEC comprises a spectrum of anomalies, mainly occurring isolated without additional congenital defects. Nevertheless, previous epidemiological studies indicated a higher association with renal, anorectal, and lower neurotubular anomalies, which may originate from the same developmental morphogenetic fields. MATERIALS AND METHODS Seventy-three prospectively (born since 2009) and 162 cross-sectional recruited EEC patients (born 1948-2008) were analyzed. Associated anomalies were derived from patient's medical data as well as from a physical examination during a physician's interview, classified according to the international statistical classification of diseases and related health problems and grouped with the London Dysmorphology Database. Descriptive statistical analyses were performed. RESULTS Majority of participants were male (68%) and expressed the classical bladder exstrophy phenotype (71%). Exstrophy variants occurred significantly more often in newborns (21%, P < .0001). Anomalies such as inguinal hernias, skeleton, and joint anomalies were equally present in both groups (P = .65 and P = .67). Heart defects were seen more often in newborns (6%) than in the cross-sectional group (1%; P = .033) and the general German population (1%). In total, 59% of the prospective and 48% of the cross-sectional patients had associated anomalies outside the spectrum (P = .16). CONCLUSION Phenomenological multicenter data confirmed the dimension of associated anomalies inside and outside the EEC spectrum. The detected anomalies are either important in preparing for the primary reconstruction or later in long-term follow-up. Associated anomalies of EEC should be spotlighted during routine check-up in all EEC patients. (C) 2018 Elsevier Inc.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ebert, Anne-KarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zwink, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenetzky, EkkehartUNSPECIFIEDorcid.org/0000-0001-5415-8784UNSPECIFIED
Stein, RaimundUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boemers, Thomas M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lacher, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fortmann, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obermayr, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fisch, MargitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mortazawi, KiaraschUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmiedeke, EberhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisenschmidt, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, MattiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hirsch, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roesch, Wolfgang H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reutter, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-140641
DOI: 10.1016/j.urology.2018.05.039
Journal or Publication Title: Urology
Volume: 123
Page Range: S. 210 - 220
Date: 2019
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1527-9995
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BLADDER EXSTROPHY; DIAGNOSIS; VARIANTSMultiple languages
Urology & NephrologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14064

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