Universität zu Köln

Klein, Sebastian, Persa, Oana-Diana, Mauch, Cornelia, Noh, Ka-Won, Pappesch, Roberto, Wagener-Ryczek, Svenja, Buettner, Reinhard, Quaas, Alexander and Hebig, Doris (2019). First report on two cases of pleomorphic dermal sarcoma successfully treated with immune checkpoint inhibitors. OncoImmunology, 8 (12). PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 2162-402X

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Abstract

Pleomorphic dermal sarcoma (PDS) is one of the most common sarcoma of the skin. Currently, limited treatment options exist for advanced stages of the disease. While immune checkpoint inhibitors (CPIs) have revolutionized cancer treatment options-their efficacy in PDS has not been explored yet. Here, we present two advanced PDS cases that showed response to anti-PD-1 therapy. Patient A had a locally metastasized PDS and reached a complete remission of the disease after eight cycles of Pembrolizumab. Patient B developed an inoperable relapse of PDS with a complete remission of the disease 4 months after treatment with Pembrolizumab in combination with radiotherapy. To our knowledge, this is the first report of two individuals with advanced PDS that successfully underwent anti-PD1 treatment. By comparing the immune micromilieu to a previously published cohort, we show that the two cases are representative for PDS tumors - potentially making these results more generalizable.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klein, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Persa, Oana-Diana UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauch, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Noh, Ka-Won UNSPECIFIED UNSPECIFIED UNSPECIFIED Pappesch, Roberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagener-Ryczek, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Hebig, Doris UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-141097
DOI:	10.1080/2162402X.2019.1665977
Journal or Publication Title:	OncoImmunology
Volume:	8
Number:	12
Date:	2019
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	2162-402X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATYPICAL FIBROXANTHOMAS; RADIATION; PEMBROLIZUMAB; IMMUNOTHERAPY; EXPRESSION; BLOCKADE; SAFETY Multiple languages Oncology; Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14109