Perez-Hansen, Antonio, Lass-Floerl, Cornelia, Lackner, Michaela, Aigner, M., Alastruey-Izquierdo, A., Arikan-Akdagli, S., Bader, O., Becker, K., Boekhout, T., Buzina, W., Cornely, O. A., Hamal, P., Kidd, S. E., Kurzai, O., Lagrou, K., Lopes Colombo, A., Mares, M., Masoud, H., Meis, J. F., Oliveri, S., Rodloff, A. C., Orth-Hoeller, D., Guerrero-Lozano, I., Sanguinetti, M., Segal, E., Taj-Aldeen, S. J., Tortorano, A. M., Trovato, L., Walther, G. and Willinger, B. (2019). Antifungal susceptibility profiles of rare ascomycetous yeasts. J. Antimicrob. Chemother., 74 (9). S. 2649 - 2657. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2091

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Abstract

Objectives: To generate antifungal susceptibility patterns for Trichomonascus ciferrii (Candida ciferrii), Candida inconspicua (Torulopsis inconspicua) and Diutina rugosa species complex (Candida rugosa species complex), and to provide key parameters such as MIC50, MIC90 and tentative epidemiological cut-off values (TECOFFs). Methods: Our strain set included isolates of clinical origin: C. inconspicua (n = 168), D. rugosa species complex (n = 90) [Candida pararugosa (n = 60), D. rugosa (n = 26) and Candida mesorugosa (n = 4)], Pichia norvegensis (Candida norvegensis) (n = 15) and T. ciferrii (n = 8). Identification was performed by MALDI-TOF MS or internal transcribed spacer sequencing. Antifungal susceptibility patterns were generated for azoles, echinocandins and amphotericin B using commercial Etest and the EUCAST broth microdilution method v7.3.1. Essential agreement (EA) was calculated for Etest and EUCAST. Results: C. inconspicua, C. pararugosa and P. norvegensis showed elevated azole MICs (MIC50 >= 0.06 mg/L), and D. rugosa and C. pararugosa elevated echinocandin MICs (MIC50 >= 0.06 mg/L). EA between methods was generally low (<90%); EA averaged 77.45%. TECOFFs were suggested for C. inconspicua and D. rugosa species complex. Conclusions: Rare yeast species tested shared high fluconazole MICs. D. rugosa species complex displayed high echinocandin MICs, while C. inconspicua and P. norvegensis were found to have high azole MICs. Overall, the agreement between EUCAST and Etest was poor and therefore MIC values generated with Etest cannot be directly compared with EUCAST results.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Perez-Hansen, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lass-Floerl, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lackner, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aigner, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alastruey-Izquierdo, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arikan-Akdagli, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bader, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boekhout, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buzina, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, O. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamal, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kidd, S. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurzai, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lagrou, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopes Colombo, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mares, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Masoud, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meis, J. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oliveri, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodloff, A. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orth-Hoeller, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guerrero-Lozano, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanguinetti, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Segal, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taj-Aldeen, S. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tortorano, A. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trovato, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walther, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Willinger, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-142409
DOI: 10.1093/jac/dkz231
Journal or Publication Title: J. Antimicrob. Chemother.
Volume: 74
Number: 9
Page Range: S. 2649 - 2657
Date: 2019
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1460-2091
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IN-VITRO ACTIVITIES; AMPHOTERICIN-B; CANDIDA-RUGOSA; EUCAST; CLSI; FLUCONAZOLE; AGENTS; ETEST; CASPOFUNGIN; SPP.Multiple languages
Infectious Diseases; Microbiology; Pharmacology & PharmacyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14240

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