Universität zu Köln

Klimpel, Annika, Luetzenburg, Tamara and Neundorf, Ines ORCID: 0000-0001-6450-3991 (2019). Recent advances of anti-cancer therapies including the use of cell-penetrating peptides. Curr. Opin. Pharmacol., 47. S. 8 - 14. OXFORD: ELSEVIER SCI LTD. ISSN 1471-4973

Full text not available from this repository.

Abstract

Cancer is one of the major growing public health problems making the development of new anti-cancer treatment strategies still compulsory. Conventionally used chemotherapies are quite often associated with severe side effects. One reason is limited cell-permeability of the used drugs resulting in only poor overall bioavailability. During the last thirty years, cell-penetrating peptides (CPPs) have extensively been studied as efficient vehicles for several classes of cargos, and the development of novel therapeutic applications including CPPs has gained a major role in current cancer research. This review summarizes recent trends in CPP-mediated cargo delivery with a future impact on anti-cancer therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klimpel, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Luetzenburg, Tamara UNSPECIFIED UNSPECIFIED UNSPECIFIED Neundorf, Ines UNSPECIFIED orcid.org/0000-0001-6450-3991 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-145140
DOI:	10.1016/j.coph.2019.01.003
Journal or Publication Title:	Curr. Opin. Pharmacol.
Volume:	47
Page Range:	S. 8 - 14
Date:	2019
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1471-4973
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SIRNA DELIVERY; IN-VITRO; CANCER; NANOPARTICLES; CONJUGATE; MEMBRANE; EFFICACY; DOXORUBICIN; LIPOSOMES; MICELLES Multiple languages Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14514