Wong, Ian C. K., Banaschewski, Tobias, Buitelaar, Jan, Cortese, Samuele, Doepfner, Manfred, Simonoff, Emily ORCID: 0000-0002-5450-0823, Coghill, David, Asherson, Phil, Santosh, Paramala, Smirnoff, Emily, Sonuga-Barke, Edmund J., Taylor, Eric, Daley, David, Hollis, Chris, Ferrin, Maite, Dittmann, Ralf W., Holtmann, Martin, Rothenberger, Aribert, Brandeis, Daniel, Steinhausen, Hans-Christoph, Danckaerts, Marina, van der Oord, Saskia, Konofal, Eric, Lecendreux, Michel, Soutullo, Cesar, Stringaris, Argyris and Zuddas, Alessandro (2019). Emerging challenges in pharmacotherapy research on attention-deficit hyperactivity disorder-outcome measures beyond symptom control and clinical trials. Lancet Psychiatry, 6 (6). S. 528 - 538. OXFORD: ELSEVIER SCI LTD. ISSN 2215-0374

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Abstract

Although pharmacological therapies are recommended as a key component in the treatment of attention-deficit hyperactivity disorder, their use continues to prompt intense debate. Despite considerable research efforts, several gaps in the knowledge base and several questions over the quality of evidence exist. Particular issues surrounding pharmacological treatments include uncertainties about long-term effectiveness and safety, safety profiles in adults, and the comparative effectiveness of different medications. In this Review, we focus on four key methodological issues for future research: (1) the use of appropriate trial designs; the need for (2) outcome measures targeting effectiveness beyond symptom control and (3) safety outcome measures; and (4) the application of clinical and administrative research databases to assess real-world outcomes. Potential solutions include increased use of randomised placebo-controlled withdrawal trials and large pharmacoepidemiological studies that use electronic health-care records on the long-term effectiveness and safety of medications. Pragmatic head-to-head randomised trials would also provide direct evidence on comparative effectiveness and safety profiles.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wong, Ian C. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Banaschewski, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buitelaar, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cortese, SamueleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doepfner, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simonoff, EmilyUNSPECIFIEDorcid.org/0000-0002-5450-0823UNSPECIFIED
Coghill, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Asherson, PhilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santosh, ParamalaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smirnoff, EmilyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sonuga-Barke, Edmund J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daley, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hollis, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferrin, MaiteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dittmann, Ralf W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holtmann, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rothenberger, AribertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandeis, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinhausen, Hans-ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danckaerts, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Oord, SaskiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konofal, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lecendreux, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soutullo, CesarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stringaris, ArgyrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuddas, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-147356
DOI: 10.1016/S2215-0366(19)30096-3
Journal or Publication Title: Lancet Psychiatry
Volume: 6
Number: 6
Page Range: S. 528 - 538
Date: 2019
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 2215-0374
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIALS; DEFICIT/HYPERACTIVITY DISORDER; NEUROPSYCHOLOGICAL OUTCOMES; FOLLOW-UP; CHILDREN; ADHD; METAANALYSIS; ADOLESCENTS; MEDICATIONMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14735

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