Bick, Ulrich ORCID: 0000-0002-7254-8572, Engel, Christoph ORCID: 0000-0002-7247-282X, Krug, Barbara, Heindel, Walter, Fallenberg, Eva M., Rhiem, Kerstin, Maintz, David, Golatta, Michael ORCID: 0000-0002-2605-0060, Speiser, Dorothee, Rjosk-Dendorfer, Dorothea, Laemmer-Skarke, Irina, Dietzel, Frederic, Schaefer, Karl Werner Fritz, Leinert, Elena, Weigel, Stefanie, Sauer, Stephanie, Pertschy, Stefanie, Hofmockel, Thomas, Hagert-Winkler, Anne, Kast, Karin, Quante, Anne, Meindl, Alfons, Kiechle, Marion, Loeffler, Markus, Schmutzler, Rita K., Blohmer, Jens-Uwe, Horn, Denise, Varon-Mateeva, Raymonda, Huebbel, Verena, Herold, Natalie, Puesken, Michael, Wimberger, Pauline, Meisel, Cornelia, Keller, Katja, Antoch, Gerald, Vesper, Anne-Sophie, Fehm, Tanja N., Schlegelberger, Brigitte, Auber, Bernd, Wallaschek, Hannah, Heil, Joerg ORCID: 0000-0002-4684-9099, Schott, Sarah, Dikow, Nicola, Mundhenke, Christoph, Arnold, Norbert ORCID: 0000-0003-4523-8808, Caliebe, Almuth, Briest, Susanne, Lemke, Johannes, Gril, Sabine, Pfeifer, Katharina, Ramser, Juliane, Mahner, Sven, Ditsch, Nina, Zeder-Goess, Christine, Tio, Joke, Burg, Matthias, Horvath, Judith, Siebert, Reiner, Bartholomae, Jasmin, Janni, Wolfgang, Bley, Thorsten, Woeckel, Achim, Haaf, Thomas, Zachariae, Silke, Bucksch, Karolin and Enders, Ute (2019). High-risk breast cancer surveillance with MRI: 10-year experience from the German consortium for hereditary breast and ovarian cancer. Breast Cancer Res. Treat., 175 (1). S. 217 - 229. NEW YORK: SPRINGER. ISSN 1573-7217

Full text not available from this repository.

Abstract

Purpose To report on 10 years of high-risk service screening with annual MRI in the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC). Methods A cohort of 4,573 high-risk, previously unaffected women (954 BRCA1 carriers, 598 BRCA2 carriers, 3021 BRCA1/2 non-carriers) participating in the GC-HBOC surveillance program was prospectively followed. Screening outcomes for 14,142 screening rounds with MRI between 2006 and 2015 were analyzed and stratified by risk group, type of screening round, and age. Results A total of 221 primary breast cancers (185 invasive, 36 in situ) were diagnosed within 12 months of an annual screening round with MRI. Of all cancers, 84.5% (174/206, 15 unknown) were stage 0 or I. In BRCA1 carriers, 16.9% (10/59, 5 unknown) of all incident cancers (screen-detected and interval cancers combined) and in BRCA2 carriers 12.5% (3/24, 4 unknown) were stage IIA or higher, compared to only 4.8% (2/42, 2 unknown) in high-risk BRCA1/2 non-carriers. Program sensitivity was 89.6% (95% CI 84.9-93.0) with no significant differences in sensitivity between risk groups or by age. Specificity was significantly lower in the first screening round (84.6%, 95% CI 83.6-85.7) than in subsequent screening rounds (91.1%, 95% CI 90.6-91.7), p < 0.001. Cancer detection rates (CDRs) and as a result positive predictive values were strongly dependent on type of screening round, risk group and patient age. CDRs ranged from 43.5 (95% CI 29.8-62.9) for the first screening round in BRCA2 carriers to 2.9 parts per thousand (95% CI 1.3-6.3) for subsequent screening rounds in high-risk non-carriers in the age group 30 to 39 years. Conclusions High-risk screening with MRI was successfully implemented in the GC-HBOC with high sensitivity and specificity. Risk prediction and inclusion criteria in high-risk non-carriers need to be adjusted to improve CDRs and thus screening efficacy in these patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bick, UlrichUNSPECIFIEDorcid.org/0000-0002-7254-8572UNSPECIFIED
Engel, ChristophUNSPECIFIEDorcid.org/0000-0002-7247-282XUNSPECIFIED
Krug, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heindel, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fallenberg, Eva M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rhiem, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maintz, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Golatta, MichaelUNSPECIFIEDorcid.org/0000-0002-2605-0060UNSPECIFIED
Speiser, DorotheeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rjosk-Dendorfer, DorotheaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laemmer-Skarke, IrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dietzel, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, Karl Werner FritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leinert, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weigel, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sauer, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pertschy, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofmockel, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hagert-Winkler, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kast, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quante, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meindl, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiechle, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loeffler, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blohmer, Jens-UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, DeniseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Varon-Mateeva, RaymondaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huebbel, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herold, NatalieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puesken, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wimberger, PaulineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meisel, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keller, KatjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antoch, GeraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vesper, Anne-SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fehm, Tanja N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlegelberger, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Auber, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallaschek, HannahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heil, JoergUNSPECIFIEDorcid.org/0000-0002-4684-9099UNSPECIFIED
Schott, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dikow, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mundhenke, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arnold, NorbertUNSPECIFIEDorcid.org/0000-0003-4523-8808UNSPECIFIED
Caliebe, AlmuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Briest, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lemke, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gril, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeifer, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramser, JulianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mahner, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ditsch, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeder-Goess, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tio, JokeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burg, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horvath, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siebert, ReinerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartholomae, JasminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janni, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bley, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woeckel, AchimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haaf, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zachariae, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bucksch, KarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Enders, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-149866
DOI: 10.1007/s10549-019-05152-9
Journal or Publication Title: Breast Cancer Res. Treat.
Volume: 175
Number: 1
Page Range: S. 217 - 229
Date: 2019
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1573-7217
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BRCA MUTATION CARRIERS; TUMOR CHARACTERISTICS; SCREENING-PROGRAM; WOMEN; MAMMOGRAPHY; AGE; GENE; USMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14986

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item