Yang, Yongjie, van der Klaauw, Agatha A., Zhu, Liangru, Cacciottolo, Tessa M., He, Yanlin ORCID: 0000-0002-5471-9016, Stadler, Lukas K. J., Wang, Chunmei, Xu, Pingwen, Saito, Kenji, Hinton, Antentor, Yan, Xiaofeng, Keogh, Julia M., Henning, Elana, Banton, Matthew C., Hendricks, Audrey E., Bochukova, Elena G., Mistry, Vanisha, Lawler, Katherine L., Liao, Lan, Xu, Jianming, O'Rahilly, Stephen, Tong, Qingchun ORCID: 0000-0002-4561-2540, Barroso, Ines, O'Malley, Bert W., Farooqi, I. Sadaf, Xu, Yong, Balasubramanian, Senduran, Clapham, Peter, Coates, Guy, Cox, Tony, Daly, Allan, Danecek, Petr, Du, Yuanping, Durbin, Richard, Edkins, Sarah, Ellis, Peter, Flicek, Paul, Guo, Xiaosen, Guo, Xueqin, Huang, Liren, Jackson, David K., Joyce, Chris, Keane, Thomas, Kolb-Kokocinski, Anja, Langford, Cordelia, Li, Yingrui, Liang, Jieqin, Lin, Hong, Liu, Ryan, Maslen, John, McCarthy, Shane, Muddyman, Dawn, Quail, Michael A., Stalker, Jim, Sun, Jianping, Tian, Jing, Wang, Guangbiao, Wang, Jun, Wang, Yu, Wong, Kim, Zhang, Pingbo, Birney, Ewan, Boustred, Chris, Brion, Marie-Jo, Chen, Lu, Clement, Gail, Danecek, Petr, Smith, George Davey ORCID: 0000-0002-1407-8314, Day, Ian N. M., Day-Williams, Aaron, Down, Thomas, Dunham, Ian, Durbin, Richard, Evans, David M., Fatemifar, Ghazaleh, Gaunt, Tom R., Geihs, Matthias, Greenwood, Celia M. T., Hart, Deborah, Howie, Bryan, Huang, Jie, Hubbard, Tim, Hysi, Pirro, Iotchkova, Valentina, Jamshidi, Yalda ORCID: 0000-0003-0151-6482, Kemp, John P., Lachance, Genevieve, Lawson, Daniel, Lek, Monkol, Lopes, Margarida, MacArthur, Daniel G., Marchini, Jonathan, Massimo, Mangino, Mathieson, Iain, McCarthy, Shane, Memari, Yasin, Metrustry, Sarah, Min, Josine L., Moayyeri, Alireza, Muddyman, Dawn, Northstone, Kate, Panoutsopoulou, Kalliope, Paternoster, Lavinia, Perry, John R. B., Quaye, Lydia, Richards, J. Brent, Ring, Susan, Ritchie, Graham R. S., Schiffels, Stephan, Shihab, Hashem A., Shin, So-Youn, Small, Kerrin S., Artigas, Maria Soler, Soranzo, Nicole, Southam, Lorraine, Spector, Timothy D., St Pourcain, Beate, Surdulescu, Gabriela, Tachmazidou, Ioanna, Timpson, Nicholas J., Tobin, Martin D., Valdes, Ana M., Visscher, Peter M., Wain, Louise V., Walter, Klaudia, Ward, Kirsten, Wilson, Scott G., Wong, Kim, Yang, Jian, Zeggini, Eleftheria, Zhang, Feng, Zheng, Hou-Feng, Anney, Richard, Ayub, Muhammad, Barrett, Jeffrey C., Blackwood, Douglas, Bolton, Patrick F., Breen, Gerome, Collier, David A., Craddock, Nick, Crooks, Lucy, Curran, Sarah, Curtis, David, Durbin, Richard, Gallagher, Louise, Geschwind, Daniel, Gurling, Hugh, Holmans, Peter, Lee, Irene, Lonnqvist, Jouko, McCarthy, Shane, McGuffin, Peter, McIntosh, Andrew M., McKechanie, Andrew G., McQuillin, Andrew ORCID: 0000-0003-1567-2240, Morris, James, Muddyman, Dawn, O'Donovan, Michael C., Owen, Michael J., Palotie, Aarno, Parr, Jeremy R., Paunio, Tiina, Pietilainen, Olli, Rehnstrom, Karola, Sharp, Sally I., Skuse, David, St Clair, David, Suvisaari, Jaana, Walters, James T. R., Williams, Hywel J., Bochukova, Elena ORCID: 0000-0003-0275-1548, Bounds, Rebecca, Dominiczak, Anna, Durbin, Richard, Keogh, Julia, Marenne, Gaelle, McCarthy, Shane, Morris, Andrew, Muddyman, Dawn, Porteous, David J., Smith, Blair H., Tachmazidou, Ioanna, Wheeler, Eleanor, Zeggini, Eleftheria, Al Turki, Saeed, Anderson, Carl A., Antony, Dinu, Beales, Phil, Bentham, Jamie, Bhattacharya, Shoumo, Calissano, Mattia, Carss, Keren, Chatterjee, Krishna, Cirak, Sebahattin, Cosgrove, Catherine, Durbin, Richard, Fitzpatrick, David R., Floyd, James, Foley, A. Reghan, Franklin, Christopher S., Futema, Marta, Grozeva, Detelina, Humphries, Steve E., Hurles, Matthew E., McCarthy, Shane, Mitchison, Hannah M., Muddyman, Dawn, Muntoni, Francesco, Onoufriadis, Alexandros, Parker, Victoria, Payne, Felicity, Plagnol, Vincent, Raymond, F. Lucy, Roberts, Nicola, Savage, David B., Scambler, Peter, Schmidts, Miriam, Schoenmakers, Nadia, Semple, Robert K., Serra, Eva, Spasic-Boskovic, Olivera, Stevens, Elizabeth, van Kogelenberg, Margriet, Vijayarangakannan, Parthiban, Walter, Klaudia, Williamson, Kathleen A., Wilson, Crispian, Whyte, Tamieka, Ciampi, Antonio, Greenwood, Celia M. T., Li, Rui, Metrustry, Sarah, Oualkacha, Karim, Tachmazidou, Ioanna, Xu, ChangJiang, Zeggini, Eleftheria, Bobrow, Martin, Bolton, Patrick F., Durbin, Richard, Fitzpatrick, David R., Griffin, Heather, Hurles, Matthew E., Kaye, Jane, Kennedy, Karen, Kent, Alastair, Muddyman, Dawn, Muntoni, Francesco, Raymond, F. Lucy, Semple, Robert K., Smee, Carol, Spector, Timothy D., Timpson, Nicholas J., Charlton, Ruth, Ekong, Rosemary, Futema, Marta, Humphries, Steve E., Khawaja, Farrah, Lopes, Luis R., Migone, Nicola, Payne, Stewart J., Plagnol, Vincent, Pollitt, Rebecca C., Povey, Sue, Ridout, Cheryl K., Robinson, Rachel L., Scott, Richard H., Shaw, Adam, Syrris, Petros, Taylor, Rohan, Vandersteen, Anthony M., Barrett, Jeffrey C., Smith, George Davey ORCID: 0000-0002-1407-8314, Durbin, Richard, Fitzpatrick, David R., Hurles, Matthew E., Kaye, Jane, Kennedy, Karen, Langford, Cordelia, McCarthy, Shane, Muddyman, Dawn, Owen, Michael J., Palotie, Aarno, Richards, J. Brent, Soranzo, Nicole, Spector, Timothy D., Stalker, Jim, Timpson, Nicholas J., Zeggini, Eleftheria, Amuzu, Antoinette, Casas, Juan Pablo, Chambers, John C., Cocca, Massimiliano, Dedoussis, George, Gambaro, Giovanni, Gasparini, Paolo, Gaunt, Tom R., Huang, Jie, Iotchkova, Valentina, Isaacs, Aaron, Johnson, Jon, Kleber, Marcus E., Kooner, Jaspal S., Langenberg, Claudia, Luan, Jian'an, Malerba, Giovanni, Marz, Winfried, Matchan, Angela, Min, Josine L., Morris, Richard, Nordestgaard, Borge G., Benn, Marianne, Ring, Susan, Scott, Robert A., Soranzo, Nicole, Southam, Lorraine, Timpson, Nicholas J., Toniolo, Daniela ORCID: 0000-0001-9545-6032, Traglia, Michela, Tybjaerg-Hansen, Anne, van Duijn, Cornelia M., van Leeuwen, Elisabeth M., Varbo, Anette, Whincup, Peter, Zaza, Gianluigi, Zeggini, Eleftheria and Zhang, Weihua (2019). Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Full text not available from this repository.

Abstract

Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants in SRC-1 found in severely obese individuals impair leptin-mediated Pomc reporter activity in cells, whilst four variants found in non-obese controls do not. In a knock-in mouse model of a loss of function human variant (SRC-1L1376P), leptin-induced depolarization of Pomc neurons and Pomc expression are significantly reduced, and food intake and body weight are increased. In summary, we demonstrate that SRC-1 modulates the function of hypothalamic Pomc neurons, and suggest that targeting SRC-1 may represent a useful therapeutic strategy for weight loss.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Yang, YongjieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Klaauw, Agatha A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhu, LiangruUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cacciottolo, Tessa M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
He, YanlinUNSPECIFIEDorcid.org/0000-0002-5471-9016UNSPECIFIED
Stadler, Lukas K. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, ChunmeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xu, PingwenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saito, KenjiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hinton, AntentorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yan, XiaofengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keogh, Julia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henning, ElanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Banton, Matthew C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hendricks, Audrey E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bochukova, Elena G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mistry, VanishaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lawler, Katherine L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liao, LanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xu, JianmingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Rahilly, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tong, QingchunUNSPECIFIEDorcid.org/0000-0002-4561-2540UNSPECIFIED
Barroso, InesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Malley, Bert W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farooqi, I. SadafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xu, YongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balasubramanian, SenduranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clapham, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coates, GuyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cox, TonyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daly, AllanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danecek, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Du, YuanpingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Durbin, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Edkins, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ellis, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flicek, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guo, XiaosenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guo, XueqinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, LirenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jackson, David K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joyce, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keane, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kolb-Kokocinski, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langford, CordeliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, YingruiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liang, JieqinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lin, HongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, RyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maslen, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McCarthy, ShaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muddyman, DawnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quail, Michael A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stalker, JimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sun, JianpingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tian, JingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, GuangbiaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, JunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, YuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wong, KimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, PingboUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Birney, EwanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boustred, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brion, Marie-JoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, LuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clement, GailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danecek, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, George DaveyUNSPECIFIEDorcid.org/0000-0002-1407-8314UNSPECIFIED
Day, Ian N. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Day-Williams, AaronUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Down, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunham, IanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Durbin, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, David M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fatemifar, GhazalehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaunt, Tom R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geihs, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greenwood, Celia M. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hart, DeborahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Howie, BryanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, JieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hubbard, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hysi, PirroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iotchkova, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jamshidi, YaldaUNSPECIFIEDorcid.org/0000-0003-0151-6482UNSPECIFIED
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Lek, MonkolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopes, MargaridaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacArthur, Daniel G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchini, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Massimo, ManginoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mathieson, IainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McCarthy, ShaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Memari, YasinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metrustry, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Min, Josine L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moayyeri, AlirezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muddyman, DawnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Northstone, KateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panoutsopoulou, KalliopeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paternoster, LaviniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perry, John R. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quaye, LydiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richards, J. BrentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ring, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Schiffels, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Shin, So-YounUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Small, Kerrin S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Artigas, Maria SolerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soranzo, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southam, LorraineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spector, Timothy D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
St Pourcain, BeateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Wong, KimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, JianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeggini, EleftheriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Zheng, Hou-FengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
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Richards, J. BrentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soranzo, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spector, Timothy D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stalker, JimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timpson, Nicholas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeggini, EleftheriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amuzu, AntoinetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Casas, Juan PabloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chambers, John C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cocca, MassimilianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dedoussis, GeorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gambaro, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gasparini, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaunt, Tom R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, JieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iotchkova, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Isaacs, AaronUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, JonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleber, Marcus E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kooner, Jaspal S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langenberg, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luan, Jian'anUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malerba, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marz, WinfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matchan, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Min, Josine L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morris, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordestgaard, Borge G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benn, MarianneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ring, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scott, Robert A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soranzo, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southam, LorraineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timpson, Nicholas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toniolo, DanielaUNSPECIFIEDorcid.org/0000-0001-9545-6032UNSPECIFIED
Traglia, MichelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tybjaerg-Hansen, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Duijn, Cornelia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Leeuwen, Elisabeth M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Varbo, AnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Whincup, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zaza, GianluigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeggini, EleftheriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, WeihuaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-150792
DOI: 10.1038/s41467-019-08737-6
Journal or Publication Title: Nat. Commun.
Volume: 10
Date: 2019
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LEPTIN RESISTANCE; PROOPIOMELANOCORTIN NEURONS; SIGNAL TRANSDUCER; SOCS-3 EXPRESSION; FOOD-INTAKE; PPAR-GAMMA; ER STRESS; OBESITY; BALANCE; FOXO1Multiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15079

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