Brandt, Marie R., Vanasschen, Christian, Ermert, Johannes ORCID: 0000-0002-2561-7766, Coenen, Heinz H. and Neumaier, Bernd ORCID: 0000-0001-5425-3116 (2019). Mn-52g/55-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity. Dalton Trans., 48 (9). S. 3003 - 3009. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1477-9234

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Abstract

trans-1,2-Diaminocyclohexane-N,N,N,N-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic Mn-55(ii) and (+)-emitting Mn-52g(ii) offers access to bimodal Positron Emission Tomography/Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r(1), a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. Mn-52g. Relaxivity measurements of the Mn-55-complex showed an enhancement of r(1) of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Brandt, Marie R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vanasschen, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ermert, JohannesUNSPECIFIEDorcid.org/0000-0002-2561-7766UNSPECIFIED
Coenen, Heinz H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, BerndUNSPECIFIEDorcid.org/0000-0001-5425-3116UNSPECIFIED
URN: urn:nbn:de:hbz:38-154083
DOI: 10.1039/c8dt04996c
Journal or Publication Title: Dalton Trans.
Volume: 48
Number: 9
Page Range: S. 3003 - 3009
Date: 2019
Publisher: ROYAL SOC CHEMISTRY
Place of Publication: CAMBRIDGE
ISSN: 1477-9234
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
O-17 NMR; MN2+ COMPLEXES; WATER EXCHANGE; MANGANESE(II); LIGANDS; SYSTEM; MN-52; MRIMultiple languages
Chemistry, Inorganic & NuclearMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15408

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