Deng, Sophie X., Borderie, Vincent, Chan, Clara C., Dana, Reza, Figueiredo, Francisco C., Gomes, Jose A. P., Pellegrini, Graziella, Shimmura, Shigeto, Kruse, Friedrich E., Cursiefen, Claus, Daya, Sheraz ORCID: 0000-0002-0025-0646, Djalilian, Ali, Frueh, Beatrice, Hjortdal, Jesper, Holland, Edward, Kaufman, Stephen, Kinoshita, Shigeru, Lee, Barry, Mannis, Mark, Merayo, Jesus, Perez, Victor, Rama, Paolo, Sangwan, Virender, Shortt, Alex, Slomovic, Allan, Solomon, Avi, Tan, Donald, Tsai, Ray, Tseng, Scheffer, Tu, Elmer, Le, Qihua, Jimena, Tatiana C. G., Sceberras, Virginia and Attico, Eustachio (2019). Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency. Cornea, 38 (3). S. 364 - 376. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-4798

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Abstract

Purpose: Despite extensive knowledge gained over the last 3 decades regarding limbal stem cell deficiency (LSCD), the disease is not clearly defined, and there is lack of agreement on the diagnostic criteria, staging, and classification system among treating physicians and research scientists working on this field. There is therefore an unmet need to obtain global consensus on the definition, classification, diagnosis, and staging of LSCD. Methods: A Limbal Stem Cell Working Group was first established by The Cornea Society in 2012. The Working Group was divided into subcommittees. Four face-to-face meetings, frequent email discussions, and teleconferences were conducted since then to obtain agreement on a strategic plan and methodology from all participants after a comprehensive literature search, and final agreement was reached on the definition, classification, diagnosis, and staging of LSCD. A writing group was formed to draft the current manuscript, which has been extensively revised to reflect the consensus of the Working Group. Results: A consensus was reached on the definition, classification, diagnosis, and staging of LSCD. The clinical presentation and diagnostic criteria of LSCD were clarified, and a staging system of LSCD based on clinical presentation was established. Conclusions: This global consensus provides a comprehensive framework for the definition, classification, diagnosis, and staging of LSCD. The newly established criteria will aid in the correct diagnosis and formulation of an appropriate treatment for different stages of LSCD, which will facilitate a better understanding of the condition and help with clinical management, research, and clinical trials in this area.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Deng, Sophie X.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borderie, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chan, Clara C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dana, RezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Figueiredo, Francisco C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomes, Jose A. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pellegrini, GraziellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shimmura, ShigetoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kruse, Friedrich E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cursiefen, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daya, SherazUNSPECIFIEDorcid.org/0000-0002-0025-0646UNSPECIFIED
Djalilian, AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frueh, BeatriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hjortdal, JesperUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holland, EdwardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaufman, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kinoshita, ShigeruUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, BarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mannis, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merayo, JesusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rama, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sangwan, VirenderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shortt, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slomovic, AllanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Solomon, AviUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, DonaldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsai, RayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tseng, SchefferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tu, ElmerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le, QihuaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jimena, Tatiana C. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sceberras, VirginiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Attico, EustachioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-154688
DOI: 10.1097/ICO.0000000000001820
Journal or Publication Title: Cornea
Volume: 38
Number: 3
Page Range: S. 364 - 376
Date: 2019
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1536-4798
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
VIVO CONFOCAL MICROSCOPY; STEVENS-JOHNSON-SYNDROME; AMNIOTIC MEMBRANE TRANSPLANTATION; OPTICAL COHERENCE TOMOGRAPHY; VERSUS-HOST-DISEASE; OCULAR SURFACE; IMPRESSION CYTOLOGY; EPITHELIAL TRANSPLANTATION; CLINICAL-FEATURES; KERATIN 13Multiple languages
OphthalmologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15468

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