Slot, Rosalinde E. R., Sikkes, Sietske A. M., Berkhof, Johannes, Brodaty, Henry, Buckley, Rachel, Cavedo, Enrica, Dardiotis, Efthimios ORCID: 0000-0003-2957-641X, Guillo-Benarous, Francoise, Hampel, Harald, Kochan, Nicole A., Lista, Simone, Luck, Tobias ORCID: 0000-0001-7551-4397, Maruff, Paul, Molinuevo, Jose Luis, Kornhuber, Johannes, Reisberg, Barry ORCID: 0000-0002-9104-7423, Riedel-Heller, Steffi G., Risacher, Shannon L., Roehr, Susanne ORCID: 0000-0001-9385-0669, Sachdev, Perminder S., Scarmeas, Nikolaos ORCID: 0000-0001-6453-8908, Scheltens, Philip ORCID: 0000-0002-1046-6408, Shulman, Melanie B., Saykin, Andrew J., Verfaillie, Sander C. J., Visser, Pieter Jelle ORCID: 0000-0001-8008-9727, Vos, Stephanie J. B., Wagner, Michael ORCID: 0000-0003-2589-6440, Wolfsgruber, Steffen, Jessen, Frank and van der Flier, Wiesje M. (2019). Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia. Alzheimers. Dement., 15 (3). S. 465 - 477. HOBOKEN: WILEY. ISSN 1552-5279

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Abstract

Introduction: In this multicenter study on subjective cognitive decline (SCD) in community-based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression to dementia. Methods: Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results: In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7], non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1 [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community-based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E epsilon 4 (1.8 [1.3-2.5]) increased the risk of dementia. Discussion: SCD can precede both AD and non-AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community-based cohorts. (C) 2018 The Authors. Published by Elsevier Inc.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Slot, Rosalinde E. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sikkes, Sietske A. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berkhof, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brodaty, HenryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buckley, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavedo, EnricaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dardiotis, EfthimiosUNSPECIFIEDorcid.org/0000-0003-2957-641XUNSPECIFIED
Guillo-Benarous, FrancoiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampel, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kochan, Nicole A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lista, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luck, TobiasUNSPECIFIEDorcid.org/0000-0001-7551-4397UNSPECIFIED
Maruff, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Molinuevo, Jose LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reisberg, BarryUNSPECIFIEDorcid.org/0000-0002-9104-7423UNSPECIFIED
Riedel-Heller, Steffi G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Risacher, Shannon L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roehr, SusanneUNSPECIFIEDorcid.org/0000-0001-9385-0669UNSPECIFIED
Sachdev, Perminder S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scarmeas, NikolaosUNSPECIFIEDorcid.org/0000-0001-6453-8908UNSPECIFIED
Scheltens, PhilipUNSPECIFIEDorcid.org/0000-0002-1046-6408UNSPECIFIED
Shulman, Melanie B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saykin, Andrew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verfaillie, Sander C. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser, Pieter JelleUNSPECIFIEDorcid.org/0000-0001-8008-9727UNSPECIFIED
Vos, Stephanie J. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Flier, Wiesje M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-155659
DOI: 10.1016/j.jalz.2018.10.003
Journal or Publication Title: Alzheimers. Dement.
Volume: 15
Number: 3
Page Range: S. 465 - 477
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1552-5279
Language: English
Faculty: Faculty of Management, Economy and Social Sciences
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BASE-LINE CHARACTERISTICS; MEMORY COMPLAINTS; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; RECRUITMENT METHODS; APOLIPOPROTEIN-E; MAJOR SUBTYPES; OLDER-ADULTS; IMPAIRMENTMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15565

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