Heeger, Christian-Hendrik, Bellmann, Barbara, Fink, Thomas, Bohnen, Jan-Eric, Wissner, Erik, Wohlmuth, Peter, Rottner, Laura, Sohns, Christian, Tilz, Roland Richard, Mathew, Shibu, Reissmann, Bruno, Lemes, Christine, Maurer, Tilman, Lueker, Jakob, Sultan, Arian, Plenge, Tobias, Goldmann, Britta, Ouyang, Feifan, Kuck, Karl-Heinz, Metzner, Ilka, Metzner, Andreas, Steven, Daniel and Rillig, Andreas (2019). Efficacy and safety of cryoballoon ablation in the elderly: A multicenter study. Int. J. Cardiol., 278. S. 108 - 114. CLARE: ELSEVIER IRELAND LTD. ISSN 1874-1754

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Abstract

Background: The prevalence of atrial fibrillation (AF) increases with age. Second-generation cryoballoon (CB2)based PVI has demonstrated encouraging clinical results in the treatment of paroxysmal (PAF) and persistent atrial fibrillation (PersAF). The objective of this study was to assess data on safety, efficacy and long-term clinical success of CB2-based pulmonary vein isolation (PVI) in patients =75 years of age. Methods: CB2-based PVI was performed in 104 patients =75 years of age (elderly group) and symptomatic AF (PersAF: n =44, 42.3%) in three highly experienced German EP centers. The data was compared to propensity score matched patients with age b75 years (n =104, control group; PersAF: n =45, 43.3%, p=0.956). Results: Themedian age of the elderly groupwas 77.5 [75, 80] yearswhile itwas 63 [52, 70] years of control group patients (p=0.0001). The median procedure time was 92.5 [75, 120] minutes (elderly group) and 100 [75, 120] (control group), p =0.124. Major complications were registered in 7/ 104 (6.7%) elderly patients and 7/ 104 (6.7%) control group patients (p =0.999). Clinical success in terms of freedom from AF recurrence after oneyear follow-up was 80% (95% CI: 72-88) and 82% (95% CI: 75-90) and after three-year follow-up 59% (95% CI: 47-74) and 49% (95% CI: 37 64) for the elderly group and the control group, respectively (p=0.7). Conclusions: CB2-based PVI in patients =75 years of age appears safe, is associated with low procedure times and shows promising clinical success rates equal to patients of the younger population. (c) 2018 Elsevier B. V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Heeger, Christian-HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bellmann, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bohnen, Jan-EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wissner, ErikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wohlmuth, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rottner, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sohns, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tilz, Roland RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mathew, ShibuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reissmann, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lemes, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maurer, TilmanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lueker, JakobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sultan, ArianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plenge, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldmann, BrittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ouyang, FeifanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuck, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzner, IlkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzner, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steven, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rillig, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-156161
DOI: 10.1016/j.ijcard.2018.09.090
Journal or Publication Title: Int. J. Cardiol.
Volume: 278
Page Range: S. 108 - 114
Date: 2019
Publisher: ELSEVIER IRELAND LTD
Place of Publication: CLARE
ISSN: 1874-1754
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PULMONARY VEIN ISOLATION; PAROXYSMAL ATRIAL-FIBRILLATION; PHRENIC-NERVE PALSY; 2016 ESC GUIDELINES; CATHETER ABLATION; RADIOFREQUENCY ABLATION; PROCEDURAL EFFICACY; 2ND-GENERATION; MANAGEMENT; COLLABORATIONMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/15616

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