Universität zu Köln

Koethe, Dagmar ORCID: 0000-0002-8324-6756, Pahlisch, Franziska, Hellmich, Martin, Rohleder, Cathrin ORCID: 0000-0002-3559-1846, Mueller, Juliane K., Meyer-Lindenberg, Andreas, Torrey, E. Fuller, Piomelli, Daniele ORCID: 0000-0002-2983-774X and Leweke, F. Markus ORCID: 0000-0002-8163-195X (2019). Familial abnormalities of endocannabinoid signaling in schizophrenia. World J. Biol. Psychiatry, 20 (2). S. 117 - 126. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1814-1412

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Abstract

Objectives: Epidemiological and experimental evidence suggests that the endocannabinoid system plays a pathophysiological role in schizophrenia. This is reflected by elevated cerebrospinal levels of the endocannabinoid anandamide in schizophrenia and its initial prodromal states. Methods: We analyzed plasma concentrations of anandamide, 2-arachidonoyl-sn-glycerol, palmitoylethanolamide and oleoylethanolamide from 25 twin pairs discordant for schizophrenia, six discordant for bipolar disorder and eight healthy twin pairs to determine hereditary traits. Results: Twin pairs discordant for schizophrenia or bipolar disorder had significantly higher levels of anandamide and palmitoylethanolamide compared to healthy twins (both P < 0.002). Non-affected twins discordant for schizophrenia, who developed a psychotic disorder within 5 years follow-up showed lower anandamide (P = 0.042) and 2-arachidonoyl-sn-glycerol levels (P = 0.049) than twins who remained healthy. Conclusions: We suggest that the protective upregulation of endocannabinoid signalling reflects either a hereditary trait or mirrors a modulating response to genetically influenced cerebral function involving, e.g., other neurotransmitters or energy metabolism.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koethe, Dagmar UNSPECIFIED orcid.org/0000-0002-8324-6756 UNSPECIFIED Pahlisch, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Rohleder, Cathrin UNSPECIFIED orcid.org/0000-0002-3559-1846 UNSPECIFIED Mueller, Juliane K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer-Lindenberg, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Torrey, E. Fuller UNSPECIFIED UNSPECIFIED UNSPECIFIED Piomelli, Daniele UNSPECIFIED orcid.org/0000-0002-2983-774X UNSPECIFIED Leweke, F. Markus UNSPECIFIED orcid.org/0000-0002-8163-195X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-156827
DOI:	10.1080/15622975.2018.1449966
Journal or Publication Title:	World J. Biol. Psychiatry
Volume:	20
Number:	2
Page Range:	S. 117 - 126
Date:	2019
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1814-1412
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TWIN PAIRS DISCORDANT; BIPOLAR DISORDER; ENDOGENOUS CANNABINOIDS; CEREBROSPINAL-FLUID; ANANDAMIDE LEVELS; PSYCHOSIS; OLEOYLETHANOLAMIDE; RECEPTOR; VOLUME; STATES Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15682