Universität zu Köln

Chen, Kevin T., Salcedo, Stephanie, Gong, Kuang ORCID: 0000-0002-2669-2610, Chonde, Daniel B., Izquierdo-Garcia, David ORCID: 0000-0003-0763-8827, Drzezga, Alexander, Rosen, Bruce, Qi, Jinyi ORCID: 0000-0002-5428-0322, Dickerson, Bradford C. and Catana, Ciprian (2019). An Efficient Approach to Perform MR-Assisted PET Data Optimization in Simultaneous PET/MR Neuroimaging Studies. J. Nucl. Med., 60 (2). S. 272 - 279. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

A main advantage of PET is that it provides quantitative measures of the radiotracer concentration, but its accuracy is confounded by factors including attenuation, subject motion, and limited spatial resolution. Using the information from one simultaneously acquired morphologic MR sequence with embedded navigators for MR motion correction (MC), we propose an efficient method, MR-assisted PET data optimization (MaPET), for attenuation correction (AC), PET MC, and anatomy-aided reconstruction. Methods: For AC, voxelwise linear attenuation coefficient maps were generated using an SPM8-based method on the MR volume. The embedded navigators were used to derive head motion estimates for event-based PET MC. The anatomy provided by the MR volume was incorporated into the PET image reconstruction using a kernel-based method. Region-based analyses were performed to assess the quality of images generated through various stages of PET data optimization. Results: The optimized PET images reconstructed with MaPET were superior in image quality to images reconstructed using only AC, with high signal-to-noise ratio and low coefficient of variation (5.08 and 0.229 in a composite cortical region compared with 3.12 and 0.570, P < 10(-4) for both comparisons). The optimized images were also shown using the Cohen's d metric to achieve a greater effect size in distinguishing cortical regions with hypometabolism from regions of preserved metabolism. Conclusion: We have shown that the spatiotemporally correlated data acquired using a single MR sequence can be used for PET attenuation, motion, and partial-volume effects corrections and that the MaPET method may enable more accurate assessment of pathologic changes in dementia and other brain disorders.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chen, Kevin T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Salcedo, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Gong, Kuang UNSPECIFIED orcid.org/0000-0002-2669-2610 UNSPECIFIED Chonde, Daniel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Izquierdo-Garcia, David UNSPECIFIED orcid.org/0000-0003-0763-8827 UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosen, Bruce UNSPECIFIED UNSPECIFIED UNSPECIFIED Qi, Jinyi UNSPECIFIED orcid.org/0000-0002-5428-0322 UNSPECIFIED Dickerson, Bradford C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Catana, Ciprian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-158267
DOI:	10.2967/jnumed.117.207142
Journal or Publication Title:	J. Nucl. Med.
Volume:	60
Number:	2
Page Range:	S. 272 - 279
Date:	2019
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEAD ATTENUATION MAPS; MOTION CORRECTION; EMISSION-TOMOGRAPHY; SEGMENTATION; IMAGES; REDUCTION; DEMENTIA Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15826