Universität zu Köln

Weigelt, Carina M., Hahn, Oliver ORCID: 0000-0001-9015-4545, Arlt, Katharina, Gruhn, Matthias, Jahn, Annika J., Esser, Jacqueline, Werner, Jennifer A., Klein, Corinna, Bueschges, Ansgar, Groenke, Sebastian and Partridge, Linda ORCID: 0000-0001-9615-0094 (2019). Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster. Life Sci. Alliance, 2 (1). COLD SPRING HARBOR: LIFE SCIENCE ALLIANCE LLC. ISSN 2575-1077

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Abstract

miRNAs are small, non-coding RNAs that regulate gene expression post-transcriptionally. We used small RNA sequencing to identify tissue-specific miRNAs in the adult brain, thorax, gut, and fat body of Drosophila melanogaster. One of the most brain-specific miRNAs that we identified was miR-210, an evolutionarily highly conserved miRNA implicated in the regulation of hypoxia in mammals. In Drosophila, we show that miR-210 is specifically expressed in sensory organs, including photoreceptors. miR-210 knockout mutants are not sensitive toward hypoxia but show progressive degradation of photoreceptor cells, accompanied by decreased photoreceptor potential, demonstrating an important function of miR-210 in photoreceptor maintenance and survival.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weigelt, Carina M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Oliver UNSPECIFIED orcid.org/0000-0001-9015-4545 UNSPECIFIED Arlt, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruhn, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Jahn, Annika J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Esser, Jacqueline UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Jennifer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Corinna UNSPECIFIED UNSPECIFIED UNSPECIFIED Bueschges, Ansgar UNSPECIFIED UNSPECIFIED UNSPECIFIED Groenke, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Partridge, Linda UNSPECIFIED orcid.org/0000-0001-9615-0094 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-158271
DOI:	10.26508/lsa.201800149
Journal or Publication Title:	Life Sci. Alliance
Volume:	2
Number:	1
Date:	2019
Publisher:	LIFE SCIENCE ALLIANCE LLC
Place of Publication:	COLD SPRING HARBOR
ISSN:	2575-1077
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIACYLGLYCEROL KINASE; GENE-EXPRESSION; HYPOXIC RESPONSE; NERVOUS-SYSTEM; MICRORNA; TARGET; INACTIVATION; PROTEIN; DIFFERENTIATION; PROLIFERATION Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15827