Universität zu Köln

Rihm, Julia S., Menz, Mareike M., Schultz, Heidrun, Bruder, Luca, Schilbach, Leonhard ORCID: 0000-0001-5547-8309, Schmid, Sebastian M. and Peters, Jan ORCID: 0000-0002-0195-5357 (2019). Sleep Deprivation Selectively Upregulates an Amygdala-Hypothalamic Circuit Involved in Food Reward. J. Neurosci., 39 (5). S. 888 - 900. WASHINGTON: SOC NEUROSCIENCE. ISSN 0270-6474

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Abstract

Sleep loss is associated with increased obesity risk, as demonstrated by correlations between sleep duration and change in body mass index or body fat percentage. Whereas previous studies linked this weight gain to disturbed endocrine parameters after sleep deprivation or restriction, neuroimaging studies revealed upregulated neural processing of food rewards after sleep loss in reward-processing areas such as the anterior cingulate cortex, ventral striatum, and insula. To address this ongoing debate between hormonal versus hedonic factors underlying sleep-loss-associated weight gain, we rigorously tested the association between sleep deprivation and food cue processing using high-resolution fMRI and assessment of hormones. After taking blood samples from 32 lean, healthy, human male participants, they underwent fMRI while performing a neuroeconomic, value-based decision-making task with snack food and trinket rewards following a full night of habitual sleep and a night of sleep deprivation in a repeated-measures crossover design. We found that des-acyl ghrelin concentrations were increased after sleep deprivation compared with habitual sleep. Despite similar hunger ratings due to fasting in both conditions, participants were willing to spend more money on food items only after sleep deprivation. Furthermore, fMRI data paralleled this behavioral finding, revealing a food-reward-specific upregulation of hypothalamic valuation signals and amygdala-hypothalamic coupling after a single night of sleep deprivation. Behavioral and fMRI results were not significantly correlated with changes in acyl, des-acyl, or total ghrelin concentrations. Our results suggest that increased food valuation after sleep loss might be due to hedonic rather than hormonal mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rihm, Julia S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Menz, Mareike M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultz, Heidrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruder, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilbach, Leonhard UNSPECIFIED orcid.org/0000-0001-5547-8309 UNSPECIFIED Schmid, Sebastian M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Jan UNSPECIFIED orcid.org/0000-0002-0195-5357 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-158789
DOI:	10.1523/JNEUROSCI.0250-18.2018
Journal or Publication Title:	J. Neurosci.
Volume:	39
Number:	5
Page Range:	S. 888 - 900
Date:	2019
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	0270-6474
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STIMULATES LOCOMOTOR-ACTIVITY; DES-ACYL GHRELIN; DIFFUSION-MODEL; ORBITOFRONTAL CORTEX; INSULIN-RESISTANCE; ELEVATED GHRELIN; PLASMA GHRELIN; REACTION-TIME; WEIGHT-GAIN; DURATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15878