Universität zu Köln

Gessner, Isabel ORCID: 0000-0001-9674-161X, Krakor, Eva, Styrnol, Sarah, Klimpel, Annika, Neundorf, Ines and Mathur, Sanjay ORCID: 0000-0003-2765-2693 (2019). Copper-free click functionalization of glucose-derived carbon spheres for tumor targeting. MRS Adv., 4 (53). S. 2881 - 2888. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 2059-8521

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Abstract

The dysfunctional metabolism of glucose in cancer cells represents a new avenue for cancer targeting based on sugar-derived carriers. Here, glucose-derived carbon spheres (CS) were prepared through a simple hydrothermal method, yielding highly homogenous spherical particles that exhibited excellent stability in aqueous solution. The abundant presence of surface hydroxyl functionalities was used for a subsequent condensation of an amino silane that was the basis for further covalent coupling strategies. CS were modified with a cyclooctyne derivative providing a highly selective binding site for copper-free click reactions. Moreover, the surface modification of CS with a dye-label allowed for their intracellular detection revealing a preferential uptake of CS, compared to silica particles, in tumor cells. These results thus demonstrate the highly promising potential of glucose-derived particles for tumor targeting applications and their efficient surface modification.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gessner, Isabel UNSPECIFIED orcid.org/0000-0001-9674-161X UNSPECIFIED Krakor, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Styrnol, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Klimpel, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Neundorf, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathur, Sanjay UNSPECIFIED orcid.org/0000-0003-2765-2693 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-159930
DOI:	10.1557/adv.2019.488
Journal or Publication Title:	MRS Adv.
Volume:	4
Number:	53
Page Range:	S. 2881 - 2888
Date:	2019
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	2059-8521
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Materials Science, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/15993