Scholz, Paula, Sitnilska, Vasilena, Hess, Jelka, Becker, Matthias ORCID: 0000-0003-4933-7010, Michels, Stephan and Fauser, Sascha (2019). COMPARISON OF RESOLUTION OF VITREOMACULAR TRACTION AFTER OCRIPLASMIN TREATMENT OR VITRECTOMY. Retin.-J. Retin. Vitr. Dis., 39 (1). S. 180 - 186. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1539-2864

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Abstract

Purpose: To compare the functional and morphologic outcome of patients with vitreomacular traction (VMT) treated with either ocriplasmin treatment or vitrectomy. Methods: Retrospective case series of patients treated with ocriplasmin or vitrectomy for VMT. Outcome measures: resolution of VMT, change in outer retinal thickness, integrity of ellipsoid zone, subretinal fluid formation, and best-corrected visual acuity 2 weeks and 4 months after treatment. Results: Fourteen eyes received ocriplasmin (Group 1). Vitreomacular traction resolved in 50% (Group 1a), and in 50%, it did not (Group 1b). Ten eyes underwent vitrectomy (Group 2). Vitreomacular traction resolved in 100%. Outer retinal thickness decreased significantly 2 weeks after treatment in Group 1 (P = 0.003) and in 1a (P = 0.018). Two weeks after treatment, Group 1a showed a disruption of the ellipsoid zone (P = 0.001) and subretinal fluid formation (P = 0.01) more often than 1b. Neither was observed 4 months after treatment. Best-corrected visual acuity decreased significantly in Groups 1 (P = 0.034) and 1a (P = 0.026). Conclusion: Most patients treated with ocriplasmin for VMT showed a transient reduction of best-corrected visual acuity, accumulation of subretinal fluid, and a loss of the ellipsoid zone after the resolution of VMT. Patients with surgical resolution of VMT did not show these findings. The advantage of a less-invasive intravitreal injection of ocriplasmin must be weighed against the lower success rate, the (transient) morphologic changes, and the uncertain visual benefit.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Scholz, PaulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sitnilska, VasilenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hess, JelkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, MatthiasUNSPECIFIEDorcid.org/0000-0003-4933-7010UNSPECIFIED
Michels, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fauser, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-160767
DOI: 10.1097/IAE.0000000000001926
Journal or Publication Title: Retin.-J. Retin. Vitr. Dis.
Volume: 39
Number: 1
Page Range: S. 180 - 186
Date: 2019
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1539-2864
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OPTICAL COHERENCE TOMOGRAPHY; INTRAVITREAL OCRIPLASMIN; MACULAR HOLE; VISION LOSS; MICROPLASMIN; ADHESIONMultiple languages
OphthalmologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/16076

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