Scholz, Paula, Sitnilska, Vasilena, Hess, Jelka, Becker, Matthias ORCID: 0000-0003-4933-7010, Michels, Stephan and Fauser, Sascha (2019). COMPARISON OF RESOLUTION OF VITREOMACULAR TRACTION AFTER OCRIPLASMIN TREATMENT OR VITRECTOMY. Retin.-J. Retin. Vitr. Dis., 39 (1). S. 180 - 186. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1539-2864
Full text not available from this repository.Abstract
Purpose: To compare the functional and morphologic outcome of patients with vitreomacular traction (VMT) treated with either ocriplasmin treatment or vitrectomy. Methods: Retrospective case series of patients treated with ocriplasmin or vitrectomy for VMT. Outcome measures: resolution of VMT, change in outer retinal thickness, integrity of ellipsoid zone, subretinal fluid formation, and best-corrected visual acuity 2 weeks and 4 months after treatment. Results: Fourteen eyes received ocriplasmin (Group 1). Vitreomacular traction resolved in 50% (Group 1a), and in 50%, it did not (Group 1b). Ten eyes underwent vitrectomy (Group 2). Vitreomacular traction resolved in 100%. Outer retinal thickness decreased significantly 2 weeks after treatment in Group 1 (P = 0.003) and in 1a (P = 0.018). Two weeks after treatment, Group 1a showed a disruption of the ellipsoid zone (P = 0.001) and subretinal fluid formation (P = 0.01) more often than 1b. Neither was observed 4 months after treatment. Best-corrected visual acuity decreased significantly in Groups 1 (P = 0.034) and 1a (P = 0.026). Conclusion: Most patients treated with ocriplasmin for VMT showed a transient reduction of best-corrected visual acuity, accumulation of subretinal fluid, and a loss of the ellipsoid zone after the resolution of VMT. Patients with surgical resolution of VMT did not show these findings. The advantage of a less-invasive intravitreal injection of ocriplasmin must be weighed against the lower success rate, the (transient) morphologic changes, and the uncertain visual benefit.
Item Type: | Journal Article | ||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-160767 | ||||||||||||||||||||||||||||
DOI: | 10.1097/IAE.0000000000001926 | ||||||||||||||||||||||||||||
Journal or Publication Title: | Retin.-J. Retin. Vitr. Dis. | ||||||||||||||||||||||||||||
Volume: | 39 | ||||||||||||||||||||||||||||
Number: | 1 | ||||||||||||||||||||||||||||
Page Range: | S. 180 - 186 | ||||||||||||||||||||||||||||
Date: | 2019 | ||||||||||||||||||||||||||||
Publisher: | LIPPINCOTT WILLIAMS & WILKINS | ||||||||||||||||||||||||||||
Place of Publication: | PHILADELPHIA | ||||||||||||||||||||||||||||
ISSN: | 1539-2864 | ||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/16076 |
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