Universität zu Köln

Gao, Xiaoyan ORCID: 0000-0001-8119-529X, Castro-Gomez, Sergio ORCID: 0000-0002-1581-474X, Grendel, Jasper, Graf, Sabine, Suesens, Ute, Binkle, Lars, Mensching, Daniel, Isbrandt, Dirk, Kuhl, Dietmar ORCID: 0000-0002-4772-6701 and Ohana, Ora (2018). Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks. Proc. Natl. Acad. Sci. U. S. A., 115 (49). S. 12531 - 12537. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and memory but remain elusive and poorly understood. Here, we present evidence that the activity-regulated and memory-linked gene Arc/Arg3.1 is transiently up-regulated in the hippocampus during the first postnatal month. Conditional removal of Arc/Arg3.1 during this period permanently alters hippocampal oscillations and diminishes spatial learning capacity throughout adulthood. In contrast, post developmental removal of Arc/Arg3.1 leaves learning and network activity patterns intact. Long-term memory storage continues to rely on Arc/Arg3.1 expression throughout life. These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning, during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gao, Xiaoyan UNSPECIFIED orcid.org/0000-0001-8119-529X UNSPECIFIED Castro-Gomez, Sergio UNSPECIFIED orcid.org/0000-0002-1581-474X UNSPECIFIED Grendel, Jasper UNSPECIFIED UNSPECIFIED UNSPECIFIED Graf, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Suesens, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Binkle, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Mensching, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Isbrandt, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhl, Dietmar UNSPECIFIED orcid.org/0000-0002-4772-6701 UNSPECIFIED Ohana, Ora UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-162445
DOI:	10.1073/pnas.1810125115
Journal or Publication Title:	Proc. Natl. Acad. Sci. U. S. A.
Volume:	115
Number:	49
Page Range:	S. 12531 - 12537
Date:	2018
Publisher:	NATL ACAD SCIENCES
Place of Publication:	WASHINGTON
ISSN:	0027-8424
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM POTENTIATION; IMMEDIATE-EARLY GENE; SHARP-WAVE RIPPLES; INFANTILE AMNESIA; CORTICAL NETWORKS; NEURONAL-ACTIVITY; MESSENGER-RNA; THETA RHYTHM; ARC; MEMORY Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/16244