Maasberg, Sebastian, Pape, Ulrich-Frank, Fottner, Christian, Goretzki, Peter E., Anlauf, Martin, Hoersch, Dieter, Cremer, Birgit, Schulte, Dominik M., Quietzsch, Detlef, Scheerer, Frank, Poeppel, Gabriele, Poeppel, Thorsten D., Begum, Nehara, Grohe, Christian and Rinke, Anja (2018). Neuroendocrine Neoplasia within the German NET Registry. Z. Gastroent., 56 (10). S. 1237 - 1247. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-7803

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Abstract

Neuroendocrine neoplasias (NEN) comprise a rare tumor entity with heterogeneous biology, prognosis and therapeutic options. Together with the recent publication of the first German guidelines on diagnostics and therapy of NEN, an analysis of the German NET-registry cohort of the German Society of Endocrinology (DGE) was performed. For this purpose, 2686 cases were extracted and their patient characteristics (e. g., age, sex, histopathological characterization, grading and staging) were displayed and outcomes were calculated. Additionally, the systemic treatment reality in the two largest subgroups, small intestinal and pancreatic NEN, was analyzed within metastatic patients. Distribution of primary tumor localization, histopathological classification, disease stage and overall survival was comparable with results from international registry studies. In concordance with current guidelines, somatostatin analogues (SSA) and peptide-receptor-radionuclide-therapy (PRRT) were the most common therapeutic modalities in small intestinal NEN. In pancreatic NEN, chemotherapy was used in first line as often as SSA. In second line, chemotherapy was used as often as PRRT. WHO-classification of 2010 and TNM staging proved to be of prognostic relevance. The current analysis of the German NET-registry characterizes a multicentric, interdisciplinary cohort of NEN patients throughout Germany and it describes the applied systemic treatment modalities and overall outcome as well as the prognostic value of the WHO classification of 2010 and TNM staging.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Maasberg, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pape, Ulrich-FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fottner, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goretzki, Peter E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anlauf, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoersch, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cremer, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulte, Dominik M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quietzsch, DetlefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheerer, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poeppel, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poeppel, Thorsten D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Begum, NeharaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grohe, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rinke, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-170501
DOI: 10.1055/a-0661-6099
Journal or Publication Title: Z. Gastroent.
Volume: 56
Number: 10
Page Range: S. 1237 - 1247
Date: 2018
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1439-7803
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ENETS CONSENSUS GUIDELINES; DIGESTIVE ENDOCRINE TUMORS; ISLET-CELL CARCINOMA; PROGNOSTIC-FACTORS; SYSTEMIC THERAPY; CLASSIFICATION; CHEMOTHERAPY; MANAGEMENT; CARE; STREPTOZOCINMultiple languages
Gastroenterology & HepatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17050

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