Universität zu Köln

Eminaga, Okyaz, Fries, Jochen ORCID: 0000-0003-2054-6345, Neiss, Susanne, Heitmann, Michaela, Woetzel, Fabian, Heidenreich, Axel, Bruns, Christiane, Alakus, Hakan and Warnecke-Eberz, Ute (2018). The upregulation of hypoxia-related miRNA 210 in primary tumor of lymphogenic metastatic prostate cancer. Epigenomics, 10 (10). S. 1347 - 1360. LONDON: FUTURE MEDICINE LTD. ISSN 1750-192X

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Abstract

Aim: To show the association between the expression level of hsa-miR-210 (miR-210) and tumor progression in prostate cancer (PCa). Methods: Quantitative PCR was performed to measure miR-210 on 55 subjects with different tumor stages; our results were then validated using three external datasets. ANOVA and Tukey's post hoc analysis were performed for comparative analyses between different tumor stages. Using the transcriptome data from The Cancer Genome Atlas for CaP, the gene expression analyses were performed on experimentally validated target genes of miR-210 identified in Tarbase and miRWalk datasets. Results & conclusion: miR-210 was significantly higher in N1 PCa compared with nonmetastatic PCa, whereas the metastatic tumor revealed a lower expression level of miR-210 than the primary tumor.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eminaga, Okyaz UNSPECIFIED UNSPECIFIED UNSPECIFIED Fries, Jochen UNSPECIFIED orcid.org/0000-0003-2054-6345 UNSPECIFIED Neiss, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Heitmann, Michaela UNSPECIFIED UNSPECIFIED UNSPECIFIED Woetzel, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Alakus, Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnecke-Eberz, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-170928
DOI:	10.2217/epi-2017-0114
Journal or Publication Title:	Epigenomics
Volume:	10
Number:	10
Page Range:	S. 1347 - 1360
Date:	2018
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1750-192X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENE-EXPRESSION; RADICAL PROSTATECTOMY; ANDROGEN RECEPTOR; PROGNOSTIC-FACTOR; MIR-210; CARCINOMA; PROGRESSION; RISK; HSA-MIR-210; RECURRENCE Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17092