Universität zu Köln

Gietzelt, Caroline, Lemke, Julia, Schaub, Friederike, Hermann, Manuel M., Dietlein, Thomas S., Cursiefen, Claus, Enders, Philip ORCID: 0000-0002-9527-4957 and Heindl, Ludwig M. (2018). Structural Reversal of Disc Cupping After Trabeculectomy Alters Bruch Membrane Opening-Based Parameters to Assess Neuroretinal Rim. Am. J. Ophthalmol., 194. S. 143 - 153. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-1891

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Abstract

OBJECTIVE: To assess the impact of trabeculectomy for glaucoma on morphometric neuroretinal parameters of the optic nerve head (ONH) using spectral-domain optical coherence tomography (SD-OCT). DESIGN: Retrospective, interventional case series. METHODS: PARTICIPANTS: Eighty-eight eyes of 88 patients who underwent trabeculectomy with mitomycin C in 2016. INTERVENTION: All patients underwent trabeculectomy in 1 eye (study eye) and had evaluable SD-OCT examinations of the ONH to measure neuroretinal tissue before and at least at 1 of the 3-, 6-, and 12-month follow-up time points after surgery. MAIN OUTCOME MEASURES: Longitudinal change in Bruch membrane opening minimum rim width (BMO-MRW), Bruch membrane opening minimum rim area (BMO-MRA), peripapillary retinal nerve fiber layer (RNFL) thickness, intraocular pressure (TOP), and mean deviation in perimetry. RESULTS: In study eyes, BMO-MRW significantly increased postsurgically comparing baseline and follow-up examinations at 3 months (P = .012), at 6 months (P = .007), and at 1 year (P = .010) after trabeculectomy. The increase in BMO-MRW 6 months after surgery correlated with IOP reduction (r = 0.48; P = .001). BMO-MRA showed an equal increase (P <= .034). RNFL thickness remained stable between baseline and follow-up at 3, 6, and 12 months and showed a moderate loss after 18 months (P = .021) of follow-up. CONCLUSIONS: Structural reversal of disc cupping after trabeculectomy markedly influences Bruch membrane opening based parameters for up to more than 1 year. Improvement in morphometry seems to correlate with the reduction of IOP while visual field function appears not to be influenced. In longitudinal follow-up of glaucoma patients by SD-OCT, evaluation of BMO-based parameters necessitates to reflect bias caused by surgery. (C) 2018 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gietzelt, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemke, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermann, Manuel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Thomas S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-171142
DOI:	10.1016/j.ajo.2018.07.016
Journal or Publication Title:	Am. J. Ophthalmol.
Volume:	194
Page Range:	S. 143 - 153
Date:	2018
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-1891
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FIBER LAYER THICKNESS; OPTICAL COHERENCE TOMOGRAPHY; INTRAOCULAR-PRESSURE ELEVATION; SCANNING LASER POLARIMETRY; NERVE HEAD; AUTOMATED SEGMENTATION; EXPERIMENTAL GLAUCOMA; LAMINA-CRIBROSA; SENSITIVITY; TOPOGRAPHY Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17114