Terry, Mary Beth, Liao, Yuyan, Kast, Karin, Antoniou, Antonis C., McDonald, Jasmine A., Mooij, Thea M., Engel, Christoph ORCID: 0000-0002-7247-282X, Nogues, Catherine, Buecher, Bruno, Mari, Veronique, Moretta-Serra, Jessica, Gladieff, Laurence, Luporsi, Elisabeth, Barrowdale, Daniel, Frost, Debra, Henderson, Alex, Brewer, Carole, Evans, D. Gareth, Eccles, Diana, Cook, Jackie, Ong, Kai-ren, Izatt, Louise, Ahmed, Munaza, Morrison, Patrick J., Dommering, Charlotte J., Oosterwijk, Jan C., Ausems, Margreet G. E. M., Kriege, Mieke, Buys, Saundra S., Andrulis, Irene L., John, Esther M., Daly, Mary, Friedlander, Michael, McLachlan, Sue Anne, Osorio, Ana ORCID: 0000-0001-8124-3984, Caldes, Trinidad, Jakubowska, Anna, Simard, Jacques, Singer, Christian F., Tan, Yen, Olah, Edith, Navratilova, Marie, Foretova, Lenka, Gerdes, Anne-Marie, Roos-Blom, Marie-Jose, Arver, Brita, Olsson, Hakan ORCID: 0000-0002-8794-9635, Schmutzler, Rita K., Hopper, John L., van Leeuwen, Flora E., Goldgar, David, Milne, Roger L., Easton, Douglas F., Rookus, Matti A., Andrieu, Nadine, Evans, Gareth, Adlard, Julian, Eeles, Ros, Davidson, Rosemarie, Tischkowitz, Marc, Snape, Katie, Walker, Lisa, Porteous, Mary, Donaldson, Alan, Morrison, Patrick, Eason, Jacqueline, Rogers, Mark, Miller, Claire, Brady, Angela, Kennedy, M. John, Barwell, Julian, Gregory, Helen, Pottinger, Caroline, Murray, Alex, Angelakos, Maggie, Dite, Gillian, Tsimiklis, Helen, Breysse, Emmanuel, Pontois, Pauline, Laborde, Lilian, Stoppa-Lyonnet, Dominique, Gauthier-Villars, Marion, Caron, Olivier, Fourme-Mouret, Emmanuelle, Fricker, Jean-Pierre, Lasset, Christine, Bonadona, Valerie, Fert-Ferrer, Sandra, Berthet, Pascaline, Venat-Bouvet, Laurence, Gilbert-Dussardier, Brigitte, Faivre, Laurence, Gesta, Paul, Sobol, Hagay, Eisinger, Francois, Longy, Michel, Dugast, Catherine, Coupier, Isabelle, Colas, Chrystelle, Soubrier, Florent, Pujol, Pascal, Corsini, Carole, Lortholary, Alain, Vennin, Philippe, Adenis, Claude, Penet, Clotilde, Delnatte, Capucine, Tinat, Julie, Tennevet, Isabelle, Limacher, Jean-Marc, Maugard, Christine, Demange, Liliane, Dreyfus, Helene, Cohen-Haguenauer, Odile, Leroux, Dominique, Zattara-Cannoni, Helene, Bera, Odile, Hogervorst, F. B. L., Adank, M. A., Schmidt, M. K., Russell, N. S., Jenner, D. J., Collee, J. M., van den Ouweland, A. M. W., Hooning, M. J., Seynaeve, C. M., van Deurzen, C. H. M., Obdeijn, I. M., van Asperen, C. J., Devilee, P., Kets, C. M., Mensenkamp, A. R., Koudijs, M. J., Aalfs, C. M., van Engelen, K., Gille, J. J. P., Gomez-Garcia, E. B., Blok, M. J., van der Hout, A. H., Mourits, M. J., de Bock, G. H., Siesling, S., Verloop, J. and van den Belt-Dusebout, A. W. (2018). The Influence of Number and Timing of Pregnancies on Breast Cancer Risk for Women With BRCA1 or BRCA2 Mutations. JNCI Cancer Spectr., 2 (4). OXFORD: OXFORD UNIV PRESS. ISSN 2515-5091

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Abstract

Background: Full-term pregnancy (FTP) is associated with a reduced breast cancer (BC) risk over time, but women are at increased BC risk in the immediate years following an FTP. No large prospective studies, however, have examined whether the number and timing of pregnancies are associated with BC risk for BRCA1 and BRCA2 mutation carriers. Methods: Using weighted and time-varying Cox proportional hazards models, we investigated whether reproductive events are associated with BC risk for mutation carriers using a retrospective cohort (5707 BRCA1 and 3525 BRCA2 mutation carriers) and a prospective cohort (2276 BRCA1 and 1610 BRCA2 mutation carriers), separately for each cohort and the combined prospective and retrospective cohort. Results: For BRCA1 mutation carriers, there was no overall association with parity compared with nulliparity (combined hazard ratio [HRc] = 0.99, 95% confidence interval [CI] = 0.83 to 1.18). Relative to being uniparous, an increased number of FTPs was associated with decreased BC risk (HRc = 0.79, 95% CI = 0.69 to 0.91; HRc =0.70, 95% CI = 0.59 to 0.82; HRc = 0.50, 95% CI = 0.40 to 0.63, for 2, 3, and >= 4 FTPs, respectively, P-trend < .0001) and increasing duration of breastfeeding was associated with decreased BC risk (combined cohort P-trend = .0003). Relative to being nulliparous, uniparous BRCA1 mutation carriers were at increased BC risk in the prospective analysis (prospective hazard ration [HRp] =1.69, 95% CI =1.09 to 2.62). For BRCA2 mutation carriers, being parous was associated with a 30% increase in BC risk (HRc =1.33, 95% CI =1.05 to 1.69), and there was no apparent decrease in risk associated with multiparity except for having at least 4 FTPs vs. 1 FTP (HRc =0.72, 95% CI = 0.54 to 0.98). Conclusions: These findings suggest differential associations with parity between BRCA1 and BRCA2 mutation carriers with higher risk for uniparous BRCA1 carriers and parous BRCA2 carriers.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Terry, Mary BethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liao, YuyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kast, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antoniou, Antonis C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McDonald, Jasmine A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mooij, Thea M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, ChristophUNSPECIFIEDorcid.org/0000-0002-7247-282XUNSPECIFIED
Nogues, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buecher, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mari, VeroniqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moretta-Serra, JessicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gladieff, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luporsi, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrowdale, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frost, DebraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henderson, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brewer, CaroleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, D. GarethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eccles, DianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cook, JackieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ong, Kai-renUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Izatt, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahmed, MunazaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morrison, Patrick J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dommering, Charlotte J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oosterwijk, Jan C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ausems, Margreet G. E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kriege, MiekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buys, Saundra S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrulis, Irene L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, Esther M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daly, MaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedlander, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McLachlan, Sue AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osorio, AnaUNSPECIFIEDorcid.org/0000-0001-8124-3984UNSPECIFIED
Caldes, TrinidadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakubowska, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simard, JacquesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singer, Christian F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, YenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olah, EdithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navratilova, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foretova, LenkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerdes, Anne-MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roos-Blom, Marie-JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arver, BritaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olsson, HakanUNSPECIFIEDorcid.org/0000-0002-8794-9635UNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, John L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Leeuwen, Flora E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldgar, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milne, Roger L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rookus, Matti A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrieu, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, GarethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adlard, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eeles, RosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davidson, RosemarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tischkowitz, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Snape, KatieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Porteous, MaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Donaldson, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morrison, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eason, JacquelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rogers, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miller, ClaireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brady, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kennedy, M. JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barwell, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gregory, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pottinger, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murray, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Angelakos, MaggieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dite, GillianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsimiklis, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breysse, EmmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pontois, PaulineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laborde, LilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoppa-Lyonnet, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gauthier-Villars, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caron, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fourme-Mouret, EmmanuelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fricker, Jean-PierreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lasset, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonadona, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fert-Ferrer, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berthet, PascalineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Venat-Bouvet, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilbert-Dussardier, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faivre, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gesta, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sobol, HagayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisinger, FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Longy, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dugast, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coupier, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colas, ChrystelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soubrier, FlorentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pujol, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corsini, CaroleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lortholary, AlainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vennin, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adenis, ClaudeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Penet, ClotildeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delnatte, CapucineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tinat, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tennevet, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Limacher, Jean-MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maugard, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demange, LilianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreyfus, HeleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cohen-Haguenauer, OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leroux, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zattara-Cannoni, HeleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bera, OdileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogervorst, F. B. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adank, M. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, M. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russell, N. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenner, D. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collee, J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Ouweland, A. M. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hooning, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seynaeve, C. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Deurzen, C. H. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obdeijn, I. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Asperen, C. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devilee, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kets, C. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mensenkamp, A. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koudijs, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aalfs, C. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Engelen, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gille, J. J. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomez-Garcia, E. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blok, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Hout, A. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mourits, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Bock, G. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siesling, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verloop, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Belt-Dusebout, A. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-172021
DOI: 10.1093/jncics/pky078
Journal or Publication Title: JNCI Cancer Spectr.
Volume: 2
Number: 4
Date: 2018
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 2515-5091
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REPRODUCTIVE FACTORS; COLLABORATIVE REANALYSIS; INDUCED-ABORTION; CARRIERS; SUSCEPTIBILITY; KCONFAB; OVARIAN; PARITY; COHORT; BIRTHMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17202

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