Universität zu Köln

Kleineberg, Nina N. ORCID: 0000-0003-2582-878X, Dovern, Anna, Binder, Ellen, Grefkes, Christian ORCID: 0000-0002-1656-720X, Eickhoff, Simon B. ORCID: 0000-0001-6363-2759, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Weiss, Peter H. ORCID: 0000-0002-5230-9080 (2018). Action and semantic tool knowledge - Effective connectivity in the underlying neural networks. Hum. Brain Mapp., 39 (9). S. 3473 - 3487. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Evidence from neuropsychological and imaging studies indicate that action and semantic knowledge about tools draw upon distinct neural substrates, but little is known about the underlying interregional effective connectivity. With fMRI and dynamic causal modeling (DCM) we investigated effective connectivity in the left-hemisphere (LH) while subjects performed (i) a function knowledge and (ii) a value knowledge task, both addressing semantic tool knowledge, and (iii) a manipulation (action) knowledge task. Overall, the results indicate crosstalk between action nodes and semantic nodes. Interestingly, effective connectivity was weakened between semantic nodes and action nodes during the manipulation task. Furthermore, pronounced modulations of effective connectivity within the fronto-parietal action system of the LH (comprising lateral occipitotemporal cortex, intraparietal sulcus, supramarginal gyrus, inferior frontal gyrus) were observed in a bidirectional manner during the processing of action knowledge. In contrast, the function and value knowledge tasks resulted in a significant strengthening of the effective connectivity between visual cortex and fusiform gyrus. Importantly, this modulation was present in both semantic tasks, indicating that processing different aspects of semantic knowledge about tools evokes similar effective connectivity patterns. Data revealed that interregional effective connectivity during the processing of tool knowledge occurred in a bidirectional manner with a weakening of connectivity between areas engaged in action and semantic knowledge about tools during the processing of action knowledge. Moreover, different semantic tool knowledge tasks elicited similar effective connectivity patterns.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kleineberg, Nina N. UNSPECIFIED orcid.org/0000-0003-2582-878X UNSPECIFIED Dovern, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Binder, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-173634
DOI:	10.1002/hbm.24188
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	39
Number:	9
Page Range:	S. 3473 - 3487
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LATERAL OCCIPITOTEMPORAL CORTEX; TUNING REVEALS INTERACTIONS; LEFT-HEMISPHERE STROKE; DYNAMIC CAUSAL-MODELS; 2 ACTION SYSTEMS; OBJECT USE; FUNCTIONAL-ORGANIZATION; MANIPULATION KNOWLEDGE; IDEATIONAL APRAXIA; PARIETAL CORTEX Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17363