Universität zu Köln

Hokamp, N. Grosse, Hoeink, A. J., Doerner, J., Jordan, D. W., Pahn, G., Persigehl, T., Maintz, D. and Haneder, S. (2018). Assessment of arterially hyper-enhancing liver lesions using virtual monoenergetic images from spectral detector CT: phantom and patient experience. Abdom. Radiol., 43 (8). S. 2066 - 2075. NEW YORK: SPRINGER. ISSN 2366-0058

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Abstract

To investigate a benefit from virtual monoenergetic reconstructions (VMIs) for assessment of arterially hyper-enhancing liver lesions in phantom and patients and to compare hybrid-iterative and spectral image reconstructions of conventional images (CI-IR and CI-SR). All imaging was performed on a SDCT (Philips Healthcare, Best, The Netherlands). Images of a non-anthropomorphic phantom with a lesion-mimicking insert (containing iodine in water solution) and arterial-phase images from contrast-enhanced patient examinations were evaluated. VMIs (40-200 keV, 10 keV increment), CI-IR, and CI-SR were reconstructed using different strengths of image denoising. ROIs were placed in lesions, liver/matrix, muscle; signal-to-noise, contrast-to-noise, and lesion-to-liver ratios (SNR, CNR, and LLR) were calculated. Qualitatively, 40, 70, and 110 keV and CI images were assessed by two radiologists on five-point Likert scales regarding overall image quality, lesion assessment, and noise. In phantoms, SNR was increased threefold by VMI40keV compared with CI-IR/SR (5.8 +/- 1.1 vs. 18.8 +/- 2.2, p ae<currency> 0.001), while no difference was found between CI-IR and CI-SR (p = 1). Denoising was capable of noise reduction by 40%. In total, 20 patients exhibiting 51 liver lesions were assessed. Attenuation was the highest in VMI40keV, while image noise was comparable to CI-IR resulting in a threefold increase of CNR/LLR (CI-IR 1.3 +/- 0.8/4.4 +/- 2.0, VMI40keV: 3.8 +/- 2.7/14.2 +/- 7.5, p ae<currency> 0.001). Subjective lesion delineation was the best in VMI40keV image (p ae<currency> 0.01), which also provided the lowest perceptible noise and the best overall image quality. VMIs improve assessment of arterially hyper-enhancing liver lesions since they increase lesion contrast while maintaining low image noise throughout the entire keV spectrum. These data suggest that to consider VMI screening after arterially hyper-enhancing liver lesions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hokamp, N. Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeink, A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doerner, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, D. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pahn, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Persigehl, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-176998
DOI:	10.1007/s00261-017-1411-1
Journal or Publication Title:	Abdom. Radiol.
Volume:	43
Number:	8
Page Range:	S. 2066 - 2075
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	2366-0058
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DUAL-ENERGY CT; KILOELECTRON VOLT SETTINGS; TO-NOISE RATIO; ITERATIVE RECONSTRUCTION; DOSE REDUCTION; PULMONARY ANGIOGRAPHY; COMPUTED-TOMOGRAPHY; ABDOMINAL CT; CONTRAST; QUALITY Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17699