Universität zu Köln

Paul, Christoph ORCID: 0000-0002-6458-0302, Heun, Christine, Mueller, Hans-Helge, Hoerauf, Hans, Feltgen, Nicolas, Wachtlin, Joachim, Kaymak, Hakan, Mennel, Stefan, Koss, Michael Janusz, Fauser, Sascha, Maier, Mathias M., Schumann, Ricarda G., Mueller, Simone, Chang, Petrus, Schmitz-Valckenberg, Steffen, Kazerounian, Sara, Szurman, Peter, Lommatzsch, Albrecht and Bertelmann, Thomas (2018). Calculating the individual probability of successful ocriplasmin treatment in eyes with VMT syndrome: a multivariable prediction model from the EXPORT study. Br. J. Ophthalmol., 102 (8). S. 1092 - 1098. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2079

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Abstract

Background/Aims To evaluate predictive factors for the treatment success of ocriplasmin and to use these factors to generate a multivariate model to calculate the individual probability of successful treatment. Methods Data were collected in a retrospective, multicentre cohort study. Patients with vitreomacular traction (VMT) syndrome without a full-thickness macular hole were included if they received an intravitreal injection (IVI) of ocriplasmin. Five factors (age, gender, lens status, presence of epiretinal membrane (ERM) formation and horizontal diameter of VMT) were assessed on their association with VMT resolution. A multivariable logistic regression model was employed to further analyse these factors and calculate the individual probability of successful treatment. Results 167 eyes of 167 patients were included. Univariate analysis revealed a significant correlation to VMT resolution for all analysed factors: age (years) (OR 0.9208; 95% CI 0.8845 to 0.9586; p<0.0001), gender (male) (OR 0.480; 95% CI 0.241 to 0.957; p=0.0371), lens status (phakic) (OR 2.042; 95% CI 1.054 to 3.958; p=0.0344), ERM formation (present) (OR 0.384; 95% CI 0.179 to 0.821; p=0.0136) and horizontal VMT diameter (mu m) (OR 0.99812; 95% CI 0.99684 to 0.99941, p=0.0042). A significant multivariable logistic regression model was established with age and VMT diameter. Conclusion Known predictive factors for VMT resolution after ocriplasmin IVI were confirmed in our study. We were able to combine them into a formula, ultimately allowing the calculation of an individual probability of treatment success with ocriplasmin in patients with VMT syndrome without FTHM.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Paul, Christoph UNSPECIFIED orcid.org/0000-0002-6458-0302 UNSPECIFIED Heun, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Hans-Helge UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoerauf, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Feltgen, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wachtlin, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaymak, Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mennel, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Koss, Michael Janusz UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Mathias M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumann, Ricarda G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Chang, Petrus UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz-Valckenberg, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kazerounian, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Szurman, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Lommatzsch, Albrecht UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertelmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-177653
DOI:	10.1136/bjophthalmol-2017-310874
Journal or Publication Title:	Br. J. Ophthalmol.
Volume:	102
Number:	8
Page Range:	S. 1092 - 1098
Date:	2018
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-2079
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VITREOMACULAR TRACTION; INTRAVITREAL OCRIPLASMIN; MACULAR HOLE; RESOLUTION; ADHESION; EXPERIENCE; OUTCOMES; EFFICACY Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17765