Universität zu Köln

Roehrig, Gabriele, Becker, Ingrid, Gutensohn, Kai and Nebe, Thomas (2018). Red blood cell counts and indices in the elderly German population. J. Lab. Med., 42 (4). S. 131 - 140. BERLIN: WALTER DE GRUYTER GMBH. ISSN 2567-9449

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Abstract

Background: Data on peripheral blood cell values in older subjects are rare. While hemoglobin (Hb) values are supposed to change with rising age, little is known about reference values for other erythrocytic blood cell counts. This cross-sectional study was initiated to analyze hematologic laboratory parameters among subjects aged >= 60 years. Methods: This was a retrospective cross-sectional study of outpatient laboratory data between January 1st and December 31st, 2015 originating from a German country-wide laboratory group; inclusion criteria: age >= 60 years, normal C-reactive protein (CRP), transferrin saturation, reticulocytes, lactate dehydrogenase, haptoglobin and soluble transferrin receptor; exclusion criteria: glomerular filtration rate (GFR) <60 mL/min, lack of inclusion criteria; primary objective: assessment of the mean Hb value; secondary objective: assessment of mean values of red blood cell (RBC) counts. Results: Of 30,611 subjects >= 60 years, 4641 met the inclusion criteria and were thus considered hematologically healthy; the following age groups were formed: 60-69 years (2094), 70-79 years (2171), 80-89 years (360), >90 years (16); median values for male/female subjects were: Hb 15.2/14.0 g/dL, RBC 5.0/4.6/mu L, mean cellular volume (MCV) 89/89/fl, mean corpuscular hemoglobin (MCH) 31/30 pg/RBC, mean corpuscular hemoglobin concentration (MCHC) 34/34 g/dL, hematocrit (hct) 44/41%. Statistical evaluation revealed a slight but significant decrease in values over age decades for all parameters except for MCH. However, all values remained within the recommended German Society of Hematology and Oncology (DGHO) reference ranges. Hb values remained above the recommended World Health Organization (WHO) cutoffs for definition of anemia. Conclusions: The results confirm the WHO reference values and are in accordance with the recommended DGHO reference values and previous results of other study cohorts outside Germany. There seems to be no need for establishing age-specific RBC or erythrocytic reference ranges for subjects >60 years.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roehrig, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Ingrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutensohn, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Nebe, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-178133
DOI:	10.1515/labmed-2017-0080
Journal or Publication Title:	J. Lab. Med.
Volume:	42
Number:	4
Page Range:	S. 131 - 140
Date:	2018
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	2567-9449
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DISTRIBUTION WIDTH; HEMOGLOBIN CONCENTRATION; REFERENCE INTERVALS; OLDER-ADULTS; ANEMIA; MORTALITY; PREVALENCE; INPATIENTS; MARKERS; HEALTH Multiple languages Medical Laboratory Technology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17813